Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes
Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their properties. In this study halloysite...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/15231/1/330.pdf |
| _version_ | 1824414292901888000 |
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| author | Sánchez Fernández, Antonio Peña Parás, Laura Vidaltamayo, Román Cué Sampedro, Rodrigo Mendoza Martinez, Ana Maria Zomosa Signoret, Viviana Chantal Rivas Estilla, Ana María Riojas, Paulina |
| author_facet | Sánchez Fernández, Antonio Peña Parás, Laura Vidaltamayo, Román Cué Sampedro, Rodrigo Mendoza Martinez, Ana Maria Zomosa Signoret, Viviana Chantal Rivas Estilla, Ana María Riojas, Paulina |
| author_sort | Sánchez Fernández, Antonio |
| collection | Repositorio Institucional |
| description | Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their
properties. In this study halloysite clay nanotubes (HNTs) were functionalized by two different organosilanes: Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and modified samples were characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Results showed a strong interaction of organosilanes with the chemical groups present in HNTs. Biocompatibility and cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma cells. Our results indicate that prior
to functionalization, HNTs show a high biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and TMPS showed high cytotoxicity by inducing apoptosis. These results allow the identification of potential applications in biomedical areas for HNTs. |
| format | Article |
| id | eprints-15231 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| record_format | eprints |
| spelling | eprints-152312019-06-26T18:54:07Z http://eprints.uanl.mx/15231/ Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes Sánchez Fernández, Antonio Peña Parás, Laura Vidaltamayo, Román Cué Sampedro, Rodrigo Mendoza Martinez, Ana Maria Zomosa Signoret, Viviana Chantal Rivas Estilla, Ana María Riojas, Paulina RA Aspectos Públicos de la Medicina TP Tecnología Química Halloysite is an aluminosilicate clay that has been widely used for controlled drug delivery, immobilization of enzymes, and for the capture of circulating tumor cells (CTCs). Surface modification of halloysite by organosilanes has been explored to improve their properties. In this study halloysite clay nanotubes (HNTs) were functionalized by two different organosilanes: Trimethoxy(propyl)silane (TMPS), and Triethoxy(octyl)silane (EOS). Untreated and modified samples were characterized by scanning electron microscopy (SEM), X-ray diffractometry (XRD), thermogravimetrical analysis (TGA), and Fourier transform infrared spectroscopy (FTIR). Results showed a strong interaction of organosilanes with the chemical groups present in HNTs. Biocompatibility and cytotoxicity of these nanomaterials were determined using C6 rat glioblastoma cells. Our results indicate that prior to functionalization, HNTs show a high biocompatibility and low cytotoxicity. However, HNTs functionalized with EOS and TMPS showed high cytotoxicity by inducing apoptosis. These results allow the identification of potential applications in biomedical areas for HNTs. 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15231/1/330.pdf http://eprints.uanl.mx/15231/1.haspreviewThumbnailVersion/330.pdf Sánchez Fernández, Antonio y Peña Parás, Laura y Vidaltamayo, Román y Cué Sampedro, Rodrigo y Mendoza Martinez, Ana Maria y Zomosa Signoret, Viviana Chantal y Rivas Estilla, Ana María y Riojas, Paulina (2014) Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes. Materials, 7 (12). pp. 7770-7780. ISSN 1996-1944 http://doi.org/10.3390/ma7127770 doi:10.3390/ma7127770 |
| spellingShingle | RA Aspectos Públicos de la Medicina TP Tecnología Química Sánchez Fernández, Antonio Peña Parás, Laura Vidaltamayo, Román Cué Sampedro, Rodrigo Mendoza Martinez, Ana Maria Zomosa Signoret, Viviana Chantal Rivas Estilla, Ana María Riojas, Paulina Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| title_full | Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| title_fullStr | Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| title_full_unstemmed | Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| title_short | Synthesization, characterization, and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| title_sort | synthesization characterization and in vitro evaluation of cytotoxicity of biomaterials based on halloysite nanotubes |
| topic | RA Aspectos Públicos de la Medicina TP Tecnología Química |
| url | http://eprints.uanl.mx/15231/1/330.pdf |
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