Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis

AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were mea...

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Autores principales: García Compeán, Diego, Jáquez Quintana, Joel Omar, Lavalle González, Fernando Javier, González González, José Alberto, Muñoz Espinosa, Linda Elsa, Villarreal Pérez, Jesús Zacarías, Maldonado Garza, Héctor Jesús
Formato: Artículo
Lenguaje:inglés
Publicado: WJG Press 2014
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Acceso en línea:http://eprints.uanl.mx/15224/1/320.pdf
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author García Compeán, Diego
Jáquez Quintana, Joel Omar
Lavalle González, Fernando Javier
González González, José Alberto
Muñoz Espinosa, Linda Elsa
Villarreal Pérez, Jesús Zacarías
Maldonado Garza, Héctor Jesús
author_facet García Compeán, Diego
Jáquez Quintana, Joel Omar
Lavalle González, Fernando Javier
González González, José Alberto
Muñoz Espinosa, Linda Elsa
Villarreal Pérez, Jesús Zacarías
Maldonado Garza, Héctor Jesús
author_sort García Compeán, Diego
collection Repositorio Institucional
description AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was performed. According to OGTT results two groups of patients were formed: those with normal glucose tolerance (NGT) and those with SAGT. Patients were followed every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model. RESULTS: Of the included patients, 30 showed NGT and 70 SAGT. Groups were significantly different only in age, INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for EndStage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease. CONCLUSION: SAGT was associated with lower survival. SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival.
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spelling eprints-152242025-07-23T15:47:28Z http://eprints.uanl.mx/15224/ Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis García Compeán, Diego Jáquez Quintana, Joel Omar Lavalle González, Fernando Javier González González, José Alberto Muñoz Espinosa, Linda Elsa Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús RC Medicina Interna, Psiquiatría, Neurología AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was performed. According to OGTT results two groups of patients were formed: those with normal glucose tolerance (NGT) and those with SAGT. Patients were followed every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model. RESULTS: Of the included patients, 30 showed NGT and 70 SAGT. Groups were significantly different only in age, INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for EndStage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease. CONCLUSION: SAGT was associated with lower survival. SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival. WJG Press 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15224/1/320.pdf http://eprints.uanl.mx/15224/1.haspreviewThumbnailVersion/320.pdf García Compeán, Diego y Jáquez Quintana, Joel Omar y Lavalle González, Fernando Javier y González González, José Alberto y Muñoz Espinosa, Linda Elsa y Villarreal Pérez, Jesús Zacarías y Maldonado Garza, Héctor Jesús (2014) Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis. World journal of gastroenterology, 20 (22). p. 7011. ISSN 1007-9327 http://doi.org/10.3748/wjg.v20.i22.7011 doi:10.3748/wjg.v20.i22.7011
spellingShingle RC Medicina Interna, Psiquiatría, Neurología
García Compeán, Diego
Jáquez Quintana, Joel Omar
Lavalle González, Fernando Javier
González González, José Alberto
Muñoz Espinosa, Linda Elsa
Villarreal Pérez, Jesús Zacarías
Maldonado Garza, Héctor Jesús
Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
title_full Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
title_fullStr Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
title_full_unstemmed Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
title_short Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
title_sort subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
topic RC Medicina Interna, Psiquiatría, Neurología
url http://eprints.uanl.mx/15224/1/320.pdf
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