Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis
AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were mea...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
WJG Press
2014
|
| Subjects: | |
| Online Access: | http://eprints.uanl.mx/15224/1/320.pdf |
| _version_ | 1838550988373360640 |
|---|---|
| author | García Compeán, Diego Jáquez Quintana, Joel Omar Lavalle González, Fernando Javier González González, José Alberto Muñoz Espinosa, Linda Elsa Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús |
| author_facet | García Compeán, Diego Jáquez Quintana, Joel Omar Lavalle González, Fernando Javier González González, José Alberto Muñoz Espinosa, Linda Elsa Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús |
| author_sort | García Compeán, Diego |
| collection | Repositorio Institucional |
| description | AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis.
METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were
included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was
performed. According to OGTT results two groups of
patients were formed: those with normal glucose tolerance
(NGT) and those with SAGT. Patients were followed
every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model.
RESULTS: Of the included patients, 30 showed NGT and
70 SAGT. Groups were significantly different only in age,
INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for EndStage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease.
CONCLUSION: SAGT was associated with lower survival.
SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival. |
| format | Article |
| id | eprints-15224 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| publisher | WJG Press |
| record_format | eprints |
| spelling | eprints-152242025-07-23T15:47:28Z http://eprints.uanl.mx/15224/ Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis García Compeán, Diego Jáquez Quintana, Joel Omar Lavalle González, Fernando Javier González González, José Alberto Muñoz Espinosa, Linda Elsa Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús RC Medicina Interna, Psiquiatría, Neurología AIM: To determine if subclinical abnormal glucose tolerance (SAGT) has influence on survival of non-diabetic patients with liver cirrhosis. METHODS: In total, 100 patients with compensated liver cirrhosis and normal fasting plasma glucose were included. Fasting plasma insulin (FPI) levels were measured, and oral glucose tolerance test (OGTT) was performed. According to OGTT results two groups of patients were formed: those with normal glucose tolerance (NGT) and those with SAGT. Patients were followed every three months. The mean follow-up was 932 d (range of 180-1925). Survival was analyzed by the Kaplan-Meyer method, and predictive factors of death were analyzed using the Cox proportional hazard regression model. RESULTS: Of the included patients, 30 showed NGT and 70 SAGT. Groups were significantly different only in age, INR, FPI and HOMA2-IR. Patients with SAGT showed lower 5-year cumulated survival than NGT patients (31.7% vs 71.6%, P = 0.02). Differences in survival were significant only after 3 years of follow-up. SAGT, Child-Pugh B, and high Child-Pugh and Model for EndStage Liver Disease (MELD) scores were independent predictors of death. The causes of death in 90.3% of cases were due to complications related to liver disease. CONCLUSION: SAGT was associated with lower survival. SAGT, Child-Pugh B, and high Child-Pugh and MELD scores were independent negative predictors of survival. WJG Press 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15224/1/320.pdf http://eprints.uanl.mx/15224/1.haspreviewThumbnailVersion/320.pdf García Compeán, Diego y Jáquez Quintana, Joel Omar y Lavalle González, Fernando Javier y González González, José Alberto y Muñoz Espinosa, Linda Elsa y Villarreal Pérez, Jesús Zacarías y Maldonado Garza, Héctor Jesús (2014) Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis. World journal of gastroenterology, 20 (22). p. 7011. ISSN 1007-9327 http://doi.org/10.3748/wjg.v20.i22.7011 doi:10.3748/wjg.v20.i22.7011 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología García Compeán, Diego Jáquez Quintana, Joel Omar Lavalle González, Fernando Javier González González, José Alberto Muñoz Espinosa, Linda Elsa Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| title_full | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| title_fullStr | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| title_full_unstemmed | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| title_short | Subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| title_sort | subclinical abnormal glucose tolerance is a predictor of death in liver cirrhosis |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/15224/1/320.pdf |
| work_keys_str_mv | AT garciacompeandiego subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT jaquezquintanajoelomar subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT lavallegonzalezfernandojavier subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT gonzalezgonzalezjosealberto subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT munozespinosalindaelsa subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT villarrealperezjesuszacarias subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis AT maldonadogarzahectorjesus subclinicalabnormalglucosetoleranceisapredictorofdeathinlivercirrhosis |