CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast
Background: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/15220/1/314.pdf |
| _version_ | 1824414288264036352 |
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| author | García Labastida, Laura Elvira Garza Guajardo, Raquel Barboza Quintana, Oralia Rodríguez Sánchez, Irám Pablo Ancer Rodríguez, Jesús Flores Gutiérrez, Juan Pablo Gómez Macías, Gabriela Sofía |
| author_facet | García Labastida, Laura Elvira Garza Guajardo, Raquel Barboza Quintana, Oralia Rodríguez Sánchez, Irám Pablo Ancer Rodríguez, Jesús Flores Gutiérrez, Juan Pablo Gómez Macías, Gabriela Sofía |
| author_sort | García Labastida, Laura Elvira |
| collection | Repositorio Institucional |
| description | Background: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma.
Results: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2.
Conclusions: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed. |
| format | Article |
| id | eprints-15220 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| record_format | eprints |
| spelling | eprints-152202023-05-24T20:32:40Z http://eprints.uanl.mx/15220/ CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast García Labastida, Laura Elvira Garza Guajardo, Raquel Barboza Quintana, Oralia Rodríguez Sánchez, Irám Pablo Ancer Rodríguez, Jesús Flores Gutiérrez, Juan Pablo Gómez Macías, Gabriela Sofía RC Medicina Interna, Psiquiatría, Neurología Background: Pure mucinous adenocarcinoma of the breast is a rare entity characterized by the production of variable amounts of mucin comprising 1% to 6% of breast carcinomas. Some mucinous adenocarcinomas have shown expression of intestinal differentiation markers such as MUC-2. This study examines the expression of intestinal differentiation markers in this type of breast carcinoma. Results: Twenty-two cases of pure mucinous adenocarcinoma of the breast were assessed. Immunochemistry was performed for beta-catenin, CDX-2 and MUC-2. All cases were positive for B-catenin. MUC-2 positivity was observed in all cases; 63. 6% were 3 plus positive. All cases were negative for CDX-2. Conclusions: These results suggest that mucinous breast carcinomas express some markers of intestinal differentiation, such as MUC-2 and beta-catenin; however, future studies with a larger series of cases and using molecular techniques that help affirm these results are needed. 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15220/1/314.pdf http://eprints.uanl.mx/15220/1.haspreviewThumbnailVersion/314.pdf García Labastida, Laura Elvira y Garza Guajardo, Raquel y Barboza Quintana, Oralia y Rodríguez Sánchez, Irám Pablo y Ancer Rodríguez, Jesús y Flores Gutiérrez, Juan Pablo y Gómez Macías, Gabriela Sofía (2014) CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast. Biological research, 47 (1). pp. 43-47. ISSN 0717-6287 http://doi.org/10.1186/0717-6287-47-43 doi:10.1186/0717-6287-47-43 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología García Labastida, Laura Elvira Garza Guajardo, Raquel Barboza Quintana, Oralia Rodríguez Sánchez, Irám Pablo Ancer Rodríguez, Jesús Flores Gutiérrez, Juan Pablo Gómez Macías, Gabriela Sofía CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| title_full | CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| title_fullStr | CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| title_full_unstemmed | CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| title_short | CDX-2, MUC-2 and B-catenin as intestinal markers in pure mucinous carcinoma of the breast |
| title_sort | cdx 2 muc 2 and b catenin as intestinal markers in pure mucinous carcinoma of the breast |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/15220/1/314.pdf |
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