Hypocholesterolemia in patients with an amebic liver abscess

Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and othe...

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Autores principales: Flores, María S., Obregón Cárdenas, Adriana, Tamez, Eva, Rodríguez Pérez, Elba Guadalupe, Arévalo Niño, Katiushka, Quintero Zapata, Isela, Tijerina Menchaca, Rolando, Bosques Padilla, Francisco Javier, Galán Wong, Luis Jesús
Formato: Artículo
Lenguaje:inglés
Publicado: 2014
Acceso en línea:http://eprints.uanl.mx/15156/1/278.pdf
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author Flores, María S.
Obregón Cárdenas, Adriana
Tamez, Eva
Rodríguez Pérez, Elba Guadalupe
Arévalo Niño, Katiushka
Quintero Zapata, Isela
Tijerina Menchaca, Rolando
Bosques Padilla, Francisco Javier
Galán Wong, Luis Jesús
author_facet Flores, María S.
Obregón Cárdenas, Adriana
Tamez, Eva
Rodríguez Pérez, Elba Guadalupe
Arévalo Niño, Katiushka
Quintero Zapata, Isela
Tijerina Menchaca, Rolando
Bosques Padilla, Francisco Javier
Galán Wong, Luis Jesús
author_sort Flores, María S.
collection Repositorio Institucional
description Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and other features, such as the size and number of abscesses, standard hematological and serum chemistry profiles, liver tests, and duration of hospital stay. Methods: A total of 108 patients with an amebic liver abscess and 140 clinically healthy volunteers were investigated. Cholesterol and triglycerides were measured in the sera. The data from medical observations and laboratory tests were obtained from the clinical records. Results: A total of 93% of patients with an amebic liver abscess showed hypocholesterolemia not related to any of the studied parameters. Liver function tests correlated with the size of the abscess. The most severe cases of amebic liver disease or death were found in patients whose cholesterol levels continued to decrease despite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemia observed in patients with an amebic liver abscess is not related to any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severity of hepatic amebiasis.
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spelling eprints-151562024-12-09T19:50:16Z http://eprints.uanl.mx/15156/ Hypocholesterolemia in patients with an amebic liver abscess Flores, María S. Obregón Cárdenas, Adriana Tamez, Eva Rodríguez Pérez, Elba Guadalupe Arévalo Niño, Katiushka Quintero Zapata, Isela Tijerina Menchaca, Rolando Bosques Padilla, Francisco Javier Galán Wong, Luis Jesús Background/Aims: Many parasites induce changes in the lipid profiles of the host. Cholesterol increases the virulence of Entamoeba histolytica in animal models and in vitro culture. This study aimed to determine, in patients with an amebic liver abscess, the correlation between cholesterol and other features, such as the size and number of abscesses, standard hematological and serum chemistry profiles, liver tests, and duration of hospital stay. Methods: A total of 108 patients with an amebic liver abscess and 140 clinically healthy volunteers were investigated. Cholesterol and triglycerides were measured in the sera. The data from medical observations and laboratory tests were obtained from the clinical records. Results: A total of 93% of patients with an amebic liver abscess showed hypocholesterolemia not related to any of the studied parameters. Liver function tests correlated with the size of the abscess. The most severe cases of amebic liver disease or death were found in patients whose cholesterol levels continued to decrease despite receiving antiamebic treatment and hospital care. Conclusions: Our results show that the hypocholesterolemia observed in patients with an amebic liver abscess is not related to any of the clinical and laboratory features analyzed. This is the first study relating hypocholesterolemia to severity of hepatic amebiasis. 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15156/1/278.pdf http://eprints.uanl.mx/15156/1.haspreviewThumbnailVersion/278.pdf Flores, María S. y Obregón Cárdenas, Adriana y Tamez, Eva y Rodríguez Pérez, Elba Guadalupe y Arévalo Niño, Katiushka y Quintero Zapata, Isela y Tijerina Menchaca, Rolando y Bosques Padilla, Francisco Javier y Galán Wong, Luis Jesús (2014) Hypocholesterolemia in patients with an amebic liver abscess. Gut and Liver, 8 (4). pp. 415-420. ISSN 1976-2283 http://doi.org/10.5009/gnl.2014.8.4.415 doi:10.5009/gnl.2014.8.4.415
spellingShingle Flores, María S.
Obregón Cárdenas, Adriana
Tamez, Eva
Rodríguez Pérez, Elba Guadalupe
Arévalo Niño, Katiushka
Quintero Zapata, Isela
Tijerina Menchaca, Rolando
Bosques Padilla, Francisco Javier
Galán Wong, Luis Jesús
Hypocholesterolemia in patients with an amebic liver abscess
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Hypocholesterolemia in patients with an amebic liver abscess
title_full Hypocholesterolemia in patients with an amebic liver abscess
title_fullStr Hypocholesterolemia in patients with an amebic liver abscess
title_full_unstemmed Hypocholesterolemia in patients with an amebic liver abscess
title_short Hypocholesterolemia in patients with an amebic liver abscess
title_sort hypocholesterolemia in patients with an amebic liver abscess
url http://eprints.uanl.mx/15156/1/278.pdf
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