The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico
Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and c...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science
2014
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| Online Access: | http://eprints.uanl.mx/15134/1/245.PDF |
| _version_ | 1824414272503939072 |
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| author | Young, Bonnie N. Rendón, Adrián Rosas Taraco, Adrián Geovanni Baker, Jack Healy, Meghan Gross, Jessica M. Long, Jeffrey Burgos, Marcos Hunley, Keith L. |
| author_facet | Young, Bonnie N. Rendón, Adrián Rosas Taraco, Adrián Geovanni Baker, Jack Healy, Meghan Gross, Jessica M. Long, Jeffrey Burgos, Marcos Hunley, Keith L. |
| author_sort | Young, Bonnie N. |
| collection | Repositorio Institucional |
| description | Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and clinical predictors of the transition from latent TB infection (LTBI) to pulmonary TB disease in an urban population in northeastern Mexico, and to examine whether genetic ancestry plays an independent role in this transition. We recruited 97 pulmonary TB disease patients and 97 LTBI individuals from a public hospital in Monterrey, Nuevo Leo´n. Socioeconomic and clinical variables were collected from interviews and medical records, and genetic ancestry was estimated for a subset of 142 study participants from 291,917 single nucleotide polymorphisms (SNPs).
We examined crude associations between the variables and TB disease status. Significant predictors from crude association tests were analyzed using multivariable logistic regression. We also compared genetic ancestry between LTBI individuals and TB disease patients at 1,314 SNPs in 273 genes from the TB biosystem in the NCBI BioSystems database. In crude association tests, 12 socioeconomic and clinical variables were associated with TB disease. Multivariable logistic regression analyses indicated that marital status, diabetes, and smoking were independently associated with TB status. Genetic ancestry was not associated with TB disease in either crude or multivariable analyses. Separate analyses showed that LTBI individuals recruited from hospital staff had significantly higher European genetic ancestry than LTBI individuals recruited from the clinics and waiting rooms. Genetic ancestry differed between individuals with LTBI and TB disease at SNPs located in two genes in the TB biosystem. These results indicate that Monterrey may be structured with respect to genetic ancestry,
and that genetic differences in TB susceptibility in parental populations may contribute to variation in disease susceptibility in the region. |
| format | Article |
| id | eprints-15134 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| publisher | Public Library of Science |
| record_format | eprints |
| spelling | eprints-151342020-06-04T16:18:06Z http://eprints.uanl.mx/15134/ The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico Young, Bonnie N. Rendón, Adrián Rosas Taraco, Adrián Geovanni Baker, Jack Healy, Meghan Gross, Jessica M. Long, Jeffrey Burgos, Marcos Hunley, Keith L. Diverse socioeconomic and clinical factors influence susceptibility to tuberculosis (TB) disease in Mexico. The role of genetic factors, particularly those that differ between the parental groups that admixed in Mexico, is unclear. The objectives of this study are to identify the socioeconomic and clinical predictors of the transition from latent TB infection (LTBI) to pulmonary TB disease in an urban population in northeastern Mexico, and to examine whether genetic ancestry plays an independent role in this transition. We recruited 97 pulmonary TB disease patients and 97 LTBI individuals from a public hospital in Monterrey, Nuevo Leo´n. Socioeconomic and clinical variables were collected from interviews and medical records, and genetic ancestry was estimated for a subset of 142 study participants from 291,917 single nucleotide polymorphisms (SNPs). We examined crude associations between the variables and TB disease status. Significant predictors from crude association tests were analyzed using multivariable logistic regression. We also compared genetic ancestry between LTBI individuals and TB disease patients at 1,314 SNPs in 273 genes from the TB biosystem in the NCBI BioSystems database. In crude association tests, 12 socioeconomic and clinical variables were associated with TB disease. Multivariable logistic regression analyses indicated that marital status, diabetes, and smoking were independently associated with TB status. Genetic ancestry was not associated with TB disease in either crude or multivariable analyses. Separate analyses showed that LTBI individuals recruited from hospital staff had significantly higher European genetic ancestry than LTBI individuals recruited from the clinics and waiting rooms. Genetic ancestry differed between individuals with LTBI and TB disease at SNPs located in two genes in the TB biosystem. These results indicate that Monterrey may be structured with respect to genetic ancestry, and that genetic differences in TB susceptibility in parental populations may contribute to variation in disease susceptibility in the region. Public Library of Science 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15134/1/245.PDF http://eprints.uanl.mx/15134/1.haspreviewThumbnailVersion/245.PDF Young, Bonnie N. y Rendón, Adrián y Rosas Taraco, Adrián Geovanni y Baker, Jack y Healy, Meghan y Gross, Jessica M. y Long, Jeffrey y Burgos, Marcos y Hunley, Keith L. (2014) The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico. PloS one, 9 (4). e94303. ISSN 1932-6203 doi:10.1371/journal.pone.0094303 |
| spellingShingle | Young, Bonnie N. Rendón, Adrián Rosas Taraco, Adrián Geovanni Baker, Jack Healy, Meghan Gross, Jessica M. Long, Jeffrey Burgos, Marcos Hunley, Keith L. The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| title_full | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| title_fullStr | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| title_full_unstemmed | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| title_short | The effects of socioeconomic status, clinical factors, and genetic ancestry on pulmonary tuberculosis disease in northeastern Mexico |
| title_sort | effects of socioeconomic status clinical factors and genetic ancestry on pulmonary tuberculosis disease in northeastern mexico |
| url | http://eprints.uanl.mx/15134/1/245.PDF |
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