Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics
Background: Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate t...
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| Format: | Article |
| Language: | English |
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2014
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| Online Access: | http://eprints.uanl.mx/15132/1/243.pdf |
| _version_ | 1824414271669272576 |
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| author | Larenas Linnemann, Désirée Michels, Alexandra Dinger, Hanna Shah Hosseini, Kijawasch Mösges, Ralph Arias Cruz, Alfredo Ambriz Moreno, María de Jesús Barajas, Martín Javier, Ruth De la Luz Cid del Prado, María Moreno, Manuel Alejandro Almaráz, Roberto García Cobas, Cecilia Yvonne García Imperial, Daniel A. Muñoz, Rosa Hernández Colín, Dante Daniel Linares Zapien, Francisco J. Luna Pech, Jorge A. Matta Campos, Juan José Jiménez, Norma Medina Ávalos, Miguel Alejandro Hernández, Alejandra Maldonado, Alberto López, Doris N. Pizano Nazara, Luis J. Sanchez, Emmanuel Ramos López, José D. Rodríguez Pérez, Noel Rodríguez Ortiz, Pablo Gabriel |
| author_facet | Larenas Linnemann, Désirée Michels, Alexandra Dinger, Hanna Shah Hosseini, Kijawasch Mösges, Ralph Arias Cruz, Alfredo Ambriz Moreno, María de Jesús Barajas, Martín Javier, Ruth De la Luz Cid del Prado, María Moreno, Manuel Alejandro Almaráz, Roberto García Cobas, Cecilia Yvonne García Imperial, Daniel A. Muñoz, Rosa Hernández Colín, Dante Daniel Linares Zapien, Francisco J. Luna Pech, Jorge A. Matta Campos, Juan José Jiménez, Norma Medina Ávalos, Miguel Alejandro Hernández, Alejandra Maldonado, Alberto López, Doris N. Pizano Nazara, Luis J. Sanchez, Emmanuel Ramos López, José D. Rodríguez Pérez, Noel Rodríguez Ortiz, Pablo Gabriel |
| author_sort | Larenas Linnemann, Désirée |
| collection | Repositorio Institucional |
| description | Background: Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age.
Methods: In a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick
testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes.
Results: 628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pollen sensitization becomes more important in the adult patients visiting
allergists (Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005).
Conclusions: In a country with (sub)tropical climate zones SPT sensitization patterns varied according to
climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen
allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen
sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens –some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries. |
| format | Article |
| id | eprints-15132 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| record_format | eprints |
| spelling | eprints-151322023-02-03T16:39:57Z http://eprints.uanl.mx/15132/ Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics Larenas Linnemann, Désirée Michels, Alexandra Dinger, Hanna Shah Hosseini, Kijawasch Mösges, Ralph Arias Cruz, Alfredo Ambriz Moreno, María de Jesús Barajas, Martín Javier, Ruth De la Luz Cid del Prado, María Moreno, Manuel Alejandro Almaráz, Roberto García Cobas, Cecilia Yvonne García Imperial, Daniel A. Muñoz, Rosa Hernández Colín, Dante Daniel Linares Zapien, Francisco J. Luna Pech, Jorge A. Matta Campos, Juan José Jiménez, Norma Medina Ávalos, Miguel Alejandro Hernández, Alejandra Maldonado, Alberto López, Doris N. Pizano Nazara, Luis J. Sanchez, Emmanuel Ramos López, José D. Rodríguez Pérez, Noel Rodríguez Ortiz, Pablo Gabriel Background: Allergen exposure leads to allergen sensitization in susceptible individuals and this might influence allergic rhinitis (AR) phenotype expression. We investigated whether sensitization patterns vary in a country with subtropical and tropical regions and if sensitization patterns relate to AR phenotypes or age. Methods: In a national, cross-sectional study AR patients (2-70 y) seen by allergists underwent blinded skin prick testing with a panel of 18 allergens and completed a validated questionnaire on AR phenotypes. Results: 628 patients were recruited. The major sensitizing allergen was house dust mite (HDM) (56%), followed by Bermuda grass (26%), ash (24%), oak (23%) and mesquite (21%) pollen, cat (22%) and cockroach (21%). Patients living in the tropical region were almost exclusively sensitized to HDM (87%). In the central agricultural zones sensitization is primarily to grass and tree pollen. Nationwide, most study subjects had perennial (82.2%), intermittent (56.5%) and moderate-severe (84.7%) AR. Sensitization was not related to the intermittent-persistent AR classification or to AR severity; seasonal AR was associated with tree (p < 0.05) and grass pollen sensitization (p < 0.01). HDM sensitization was more frequent in children (0-11 y) and adolescents (12-17 y) (subtropical region: p < 0.0005; tropical region p < 0.05), but pollen sensitization becomes more important in the adult patients visiting allergists (Adults vs children + adolescents for tree pollen: p < 0.0001, weeds: p < 0.0005). Conclusions: In a country with (sub)tropical climate zones SPT sensitization patterns varied according to climatological zones; they were different from those found in Europe, HDM sensitization far outweighing pollen allergies and Bermuda grass and Ash pollen being the main grass and tree allergens, respectively. Pollen sensitization was related to SAR, but no relation between sensitization and intermittent-persistent AR or AR severity could be detected. Sensitization patterns vary with age (child HDM, adult pollen). Clinical implications of our findings are dual: only a few allergens –some region specific- cover the majority of sensitizations in (sub)tropical climate zones. This is of major importance for allergen manufacturers and immunotherapy planning. Secondly, patient selection in clinical trials should be based on the intermittent-persistent and severity classifications, rather than on the seasonal-perennial AR subtypes, especially when conducted in (sub)tropical countries. 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15132/1/243.pdf http://eprints.uanl.mx/15132/1.haspreviewThumbnailVersion/243.pdf Larenas Linnemann, Désirée y Michels, Alexandra y Dinger, Hanna y Shah Hosseini, Kijawasch y Mösges, Ralph y Arias Cruz, Alfredo y Ambriz Moreno, María de Jesús y Barajas, Martín y Javier, Ruth y De la Luz Cid del Prado, María y Moreno, Manuel Alejandro y Almaráz, Roberto y García Cobas, Cecilia Yvonne y García Imperial, Daniel A. y Muñoz, Rosa y Hernández Colín, Dante Daniel y Linares Zapien, Francisco J. y Luna Pech, Jorge A. y Matta Campos, Juan José y Jiménez, Norma y Medina Ávalos, Miguel Alejandro y Hernández, Alejandra y Maldonado, Alberto y López, Doris N. y Pizano Nazara, Luis J. y Sanchez, Emmanuel y Ramos López, José D. y Rodríguez Pérez, Noel y Rodríguez Ortiz, Pablo Gabriel (2014) Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics. Clinical and translational allergy, 4 (1). p. 20. ISSN 2045-7022 http://doi.org/10.1186/2045-7022-4-20 doi:10.1186/2045-7022-4-20 |
| spellingShingle | Larenas Linnemann, Désirée Michels, Alexandra Dinger, Hanna Shah Hosseini, Kijawasch Mösges, Ralph Arias Cruz, Alfredo Ambriz Moreno, María de Jesús Barajas, Martín Javier, Ruth De la Luz Cid del Prado, María Moreno, Manuel Alejandro Almaráz, Roberto García Cobas, Cecilia Yvonne García Imperial, Daniel A. Muñoz, Rosa Hernández Colín, Dante Daniel Linares Zapien, Francisco J. Luna Pech, Jorge A. Matta Campos, Juan José Jiménez, Norma Medina Ávalos, Miguel Alejandro Hernández, Alejandra Maldonado, Alberto López, Doris N. Pizano Nazara, Luis J. Sanchez, Emmanuel Ramos López, José D. Rodríguez Pérez, Noel Rodríguez Ortiz, Pablo Gabriel Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| title_full | Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| title_fullStr | Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| title_full_unstemmed | Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| title_short | Allergen sensitization linked to climate and age, not to intermittent-persistent rhinitis in a cross-sectional cohort study in the (sub)tropics |
| title_sort | allergen sensitization linked to climate and age not to intermittent persistent rhinitis in a cross sectional cohort study in the sub tropics |
| url | http://eprints.uanl.mx/15132/1/243.pdf |
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