The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus
Background: Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue viruses in Ae. aegypti populations in...
| Autores principales: | , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
Public Library of Science
2009
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| Acceso en línea: | http://eprints.uanl.mx/15100/1/791.pdf |
| _version_ | 1824414259043368960 |
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| author | Gubler, Duane J. Lozano Fuentes, Saúl Fernández Salas, Ildefonso Muñoz, María de Lourdes García Rejón, Julián Everardo Olson, Ken E. Beaty, Barry J. Black, William C. |
| author_facet | Gubler, Duane J. Lozano Fuentes, Saúl Fernández Salas, Ildefonso Muñoz, María de Lourdes García Rejón, Julián Everardo Olson, Ken E. Beaty, Barry J. Black, William C. |
| author_sort | Gubler, Duane J. |
| collection | Repositorio Institucional |
| description | Background: Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue viruses in Ae. aegypti populations in Mexico. Methodology/Principal Findings: Population genetic studies revealed that the intersection of the Neovolcanic axis (NVA) with the Gulf of Mexico coast in the state of Veracruz acts as a discrete barrier to gene flow among Ae. aegypti populations north and south of the NVA. The mosquito populations north and south of the NVA also differed in their vector competence (VC) for dengue serotype 2 virus (DENV2). The average VC rate for Ae. aegypti mosquitoes from populations from north of the NVA was 0.55; in contrast the average VC rate for mosquitoes from populations from south of the NVA was 0.20. Most of this variation was attributable to a midgut infection and escape barriers. In Ae. aegypti north of the NVA 21.5% failed to develop midgut infections and 30.3% of those with an infected midgut failed to develop a disseminated infection. In contrast, south of the NVA 45.2% failed to develop midgut infections and 62.8% of those with an infected midgut failed to develop a disseminated infection. Conclusions: Barriers to gene flow in vector populations may also impact the frequency of genes that condition continuous and epidemiologically relevant traits such as vector competence. Further studies are warranted to determine why the NVA is a barrier to gene flow and to determine whether the differences in vector competence seen north and south of the NVA are stable and epidemiologically significant. |
| format | Article |
| id | eprints-15100 |
| institution | UANL |
| language | English |
| publishDate | 2009 |
| publisher | Public Library of Science |
| record_format | eprints |
| spelling | eprints-151002021-05-10T15:30:48Z http://eprints.uanl.mx/15100/ The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus Gubler, Duane J. Lozano Fuentes, Saúl Fernández Salas, Ildefonso Muñoz, María de Lourdes García Rejón, Julián Everardo Olson, Ken E. Beaty, Barry J. Black, William C. Background: Aedes aegypti is the main mosquito vector of the four serotypes of dengue virus (DENV). Previous population genetic and vector competence studies have demonstrated substantial genetic structure and major differences in the ability to transmit dengue viruses in Ae. aegypti populations in Mexico. Methodology/Principal Findings: Population genetic studies revealed that the intersection of the Neovolcanic axis (NVA) with the Gulf of Mexico coast in the state of Veracruz acts as a discrete barrier to gene flow among Ae. aegypti populations north and south of the NVA. The mosquito populations north and south of the NVA also differed in their vector competence (VC) for dengue serotype 2 virus (DENV2). The average VC rate for Ae. aegypti mosquitoes from populations from north of the NVA was 0.55; in contrast the average VC rate for mosquitoes from populations from south of the NVA was 0.20. Most of this variation was attributable to a midgut infection and escape barriers. In Ae. aegypti north of the NVA 21.5% failed to develop midgut infections and 30.3% of those with an infected midgut failed to develop a disseminated infection. In contrast, south of the NVA 45.2% failed to develop midgut infections and 62.8% of those with an infected midgut failed to develop a disseminated infection. Conclusions: Barriers to gene flow in vector populations may also impact the frequency of genes that condition continuous and epidemiologically relevant traits such as vector competence. Further studies are warranted to determine why the NVA is a barrier to gene flow and to determine whether the differences in vector competence seen north and south of the NVA are stable and epidemiologically significant. Public Library of Science 2009 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15100/1/791.pdf http://eprints.uanl.mx/15100/1.haspreviewThumbnailVersion/791.pdf Gubler, Duane J. y Lozano Fuentes, Saúl y Fernández Salas, Ildefonso y Muñoz, María de Lourdes y García Rejón, Julián Everardo y Olson, Ken E. y Beaty, Barry J. y Black, William C. (2009) The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus. PloS Neglected tropical diseases, 3 (6). e468. ISSN 1935-2727 http://doi.org/10.1371/journal.pntd.0000468 doi:10.1371/journal.pntd.0000468 |
| spellingShingle | Gubler, Duane J. Lozano Fuentes, Saúl Fernández Salas, Ildefonso Muñoz, María de Lourdes García Rejón, Julián Everardo Olson, Ken E. Beaty, Barry J. Black, William C. The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| title_full | The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| title_fullStr | The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| title_full_unstemmed | The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| title_short | The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus |
| title_sort | neovolcanic axis is a barrier to gene flow among aedes aegypti populations in mexico that differ in vector competence for dengue 2 virus |
| url | http://eprints.uanl.mx/15100/1/791.pdf |
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