Mode of antiviral action of silver nanoparticles against HIV-1
Background: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2010
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| Acceso en línea: | http://eprints.uanl.mx/15088/1/761.pdf |
| _version_ | 1824414254192656384 |
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| author | Lara Villegas, Humberto Herman Ayala Núñez, Nilda Vanesa Ixtepan Turrent, Liliana del Carmen Rodríguez Padilla, Cristina |
| author_facet | Lara Villegas, Humberto Herman Ayala Núñez, Nilda Vanesa Ixtepan Turrent, Liliana del Carmen Rodríguez Padilla, Cristina |
| author_sort | Lara Villegas, Humberto Herman |
| collection | Repositorio Institucional |
| description | Background: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. Results: Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cellfree virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle. Conclusions: These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains. |
| format | Article |
| id | eprints-15088 |
| institution | UANL |
| language | English |
| publishDate | 2010 |
| record_format | eprints |
| spelling | eprints-150882024-12-11T15:27:28Z http://eprints.uanl.mx/15088/ Mode of antiviral action of silver nanoparticles against HIV-1 Lara Villegas, Humberto Herman Ayala Núñez, Nilda Vanesa Ixtepan Turrent, Liliana del Carmen Rodríguez Padilla, Cristina Background: Silver nanoparticles have proven to exert antiviral activity against HIV-1 at non-cytotoxic concentrations, but the mechanism underlying their HIV-inhibitory activity has not been not fully elucidated. In this study, silver nanoparticles are evaluated to elucidate their mode of antiviral action against HIV-1 using a panel of different in vitro assays. Results: Our data suggest that silver nanoparticles exert anti-HIV activity at an early stage of viral replication, most likely as a virucidal agent or as an inhibitor of viral entry. Silver nanoparticles bind to gp120 in a manner that prevents CD4-dependent virion binding, fusion, and infectivity, acting as an effective virucidal agent against cellfree virus (laboratory strains, clinical isolates, T and M tropic strains, and resistant strains) and cell-associated virus. Besides, silver nanoparticles inhibit post-entry stages of the HIV-1 life cycle. Conclusions: These properties make them a broad-spectrum agent not prone to inducing resistance that could be used preventively against a wide variety of circulating HIV-1 strains. 2010 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15088/1/761.pdf http://eprints.uanl.mx/15088/1.haspreviewThumbnailVersion/761.pdf Lara Villegas, Humberto Herman y Ayala Núñez, Nilda Vanesa y Ixtepan Turrent, Liliana del Carmen y Rodríguez Padilla, Cristina (2010) Mode of antiviral action of silver nanoparticles against HIV-1. Journal of Nanobiotechnology, 8 (1). p. 1. ISSN 1477-3155 http://doi.org/10.1186/1477-3155-8-1 doi:10.1186/1477-3155-8-1 |
| spellingShingle | Lara Villegas, Humberto Herman Ayala Núñez, Nilda Vanesa Ixtepan Turrent, Liliana del Carmen Rodríguez Padilla, Cristina Mode of antiviral action of silver nanoparticles against HIV-1 |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Mode of antiviral action of silver nanoparticles against HIV-1 |
| title_full | Mode of antiviral action of silver nanoparticles against HIV-1 |
| title_fullStr | Mode of antiviral action of silver nanoparticles against HIV-1 |
| title_full_unstemmed | Mode of antiviral action of silver nanoparticles against HIV-1 |
| title_short | Mode of antiviral action of silver nanoparticles against HIV-1 |
| title_sort | mode of antiviral action of silver nanoparticles against hiv 1 |
| url | http://eprints.uanl.mx/15088/1/761.pdf |
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