Molecular annotation of ketol-acid reductoisomerases fromStreptomycesreveals a novel amino acid biosynthesis interlock mediated by enzyme promiscuity
The 6-phosphogluconate dehydrogenase superfamily oxidize and reduce a wide range of substrates, making their functional annotation challenging. Ketolacid reductoisomerase (KARI), encoded by the ilvC gene in branched-chain amino acids biosynthesis, is a promiscuous reductase enzyme within this supe...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2014
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| Acceso en línea: | http://eprints.uanl.mx/15043/1/204.pdf |