Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses
Objective: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations. The...
| Autores principales: | , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2012
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| Acceso en línea: | http://eprints.uanl.mx/15038/1/658.pdf |
| _version_ | 1824414233761153024 |
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| author | Tamez Pérez, Héctor Eloy Gómez de Ossio, María Dolores Quintanilla Flores, Dania Lizet Hernández Coria, Mayra Ivonne Tamez Peña, Alejandra Lorena Cuz Pérez, Gissén Jazmín Proskauer Peña, Stephanie Lissette |
| author_facet | Tamez Pérez, Héctor Eloy Gómez de Ossio, María Dolores Quintanilla Flores, Dania Lizet Hernández Coria, Mayra Ivonne Tamez Peña, Alejandra Lorena Cuz Pérez, Gissén Jazmín Proskauer Peña, Stephanie Lissette |
| author_sort | Tamez Pérez, Héctor Eloy |
| collection | Repositorio Institucional |
| description | Objective: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations. The purpose of this report is to determine the metabolic changes in blood glucose levels in non-diabetic patients receiving methylprednisolone pulses and identify the presence of predictive factors for its development. Methods: Observational, prospective study in 50 non-diabetic patients receiving 1 g intravenous methylprednisolone pulses for three consecutive days as an indication for diverse autoimmune disorders. Demographic, anthropometric, and metabolic variables were analyzed, and glucose, insulin and C-peptide levels after each steroid pulse were identified. Different variables and the magnitude of hyperglycemia were analyzed using Pearson’s correlation. Results: 50 patients were included, predominantly women (66%, n = 33). The average age was 41 ± 14 years with a BMI of 26 ± 3 kg/m2 . Baseline glucose was 83 ± 10 mg/dL. After each steroid pulse, glucose increased to 140 ± 28, 160 ± 38 and 183 ± 44, respectively (p <0.001).
C-peptide and insulin concentrations increased significantly (p <0.001). The prevalence of fasting hyperglycemia after each pulse was 68%, 94% and 98%, respectively. We found no correlation between the magnitude of hyperglycemia and the studied variables. Conclusion: Methylprednisolone pulses produced significant increases in fasting glucose in most patients without diabetes. Further studies are needed to define its role in long-term consequences. |
| format | Article |
| id | eprints-15038 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| record_format | eprints |
| spelling | eprints-150382021-07-19T15:27:06Z http://eprints.uanl.mx/15038/ Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses Tamez Pérez, Héctor Eloy Gómez de Ossio, María Dolores Quintanilla Flores, Dania Lizet Hernández Coria, Mayra Ivonne Tamez Peña, Alejandra Lorena Cuz Pérez, Gissén Jazmín Proskauer Peña, Stephanie Lissette Objective: Methylprednisolone pulses are used in a variety of disease conditions, both for acute and chronic therapy. Although well tolerated, they increase glucose levels in both non-diabetic and diabetic patients. They may also be considered a significant risk for acute metabolic alterations. The purpose of this report is to determine the metabolic changes in blood glucose levels in non-diabetic patients receiving methylprednisolone pulses and identify the presence of predictive factors for its development. Methods: Observational, prospective study in 50 non-diabetic patients receiving 1 g intravenous methylprednisolone pulses for three consecutive days as an indication for diverse autoimmune disorders. Demographic, anthropometric, and metabolic variables were analyzed, and glucose, insulin and C-peptide levels after each steroid pulse were identified. Different variables and the magnitude of hyperglycemia were analyzed using Pearson’s correlation. Results: 50 patients were included, predominantly women (66%, n = 33). The average age was 41 ± 14 years with a BMI of 26 ± 3 kg/m2 . Baseline glucose was 83 ± 10 mg/dL. After each steroid pulse, glucose increased to 140 ± 28, 160 ± 38 and 183 ± 44, respectively (p <0.001). C-peptide and insulin concentrations increased significantly (p <0.001). The prevalence of fasting hyperglycemia after each pulse was 68%, 94% and 98%, respectively. We found no correlation between the magnitude of hyperglycemia and the studied variables. Conclusion: Methylprednisolone pulses produced significant increases in fasting glucose in most patients without diabetes. Further studies are needed to define its role in long-term consequences. 2012 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/15038/1/658.pdf http://eprints.uanl.mx/15038/1.haspreviewThumbnailVersion/658.pdf Tamez Pérez, Héctor Eloy y Gómez de Ossio, María Dolores y Quintanilla Flores, Dania Lizet y Hernández Coria, Mayra Ivonne y Tamez Peña, Alejandra Lorena y Cuz Pérez, Gissén Jazmín y Proskauer Peña, Stephanie Lissette (2012) Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses. Revista da Associação Médica Brasileira, 58 (1). pp. 125-128. ISSN 01044230 http://doi.org/10.1590/S0104-42302012000100025 doi:10.1590/S0104-42302012000100025 |
| spellingShingle | Tamez Pérez, Héctor Eloy Gómez de Ossio, María Dolores Quintanilla Flores, Dania Lizet Hernández Coria, Mayra Ivonne Tamez Peña, Alejandra Lorena Cuz Pérez, Gissén Jazmín Proskauer Peña, Stephanie Lissette Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| title_full | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| title_fullStr | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| title_full_unstemmed | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| title_short | Glucose disturbances in non-diabetic patients receiving acute treatment with methylprednisolone pulses |
| title_sort | glucose disturbances in non diabetic patients receiving acute treatment with methylprednisolone pulses |
| url | http://eprints.uanl.mx/15038/1/658.pdf |
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