Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer
Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in patients with breast cancer, but some patients may be more susceptible to ionizing radiation, and increased exposure to radiation sources may be associated to radiation adverse events. This susceptibility may...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
2015
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| Online Access: | http://eprints.uanl.mx/14941/1/112.pdf |
| _version_ | 1824414197810724864 |
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| author | Borrego Soto, Gissela Ortiz López, Rocío Rojas Martínez, Augusto |
| author_facet | Borrego Soto, Gissela Ortiz López, Rocío Rojas Martínez, Augusto |
| author_sort | Borrego Soto, Gissela |
| collection | Repositorio Institucional |
| description | Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in patients with breast
cancer, but some patients may be more susceptible to ionizing radiation, and increased exposure to radiation
sources may be associated to radiation adverse events. This susceptibility may be related to deficiencies in DNA repair mechanisms that are activated after cell-radiation, which causes DNA damage, particularly DNA double strand breaks. Some of these genetic susceptibilities in DNA-repair mechanisms are implicated in the etiology of hereditary breast/ovarian cancer (pathologic mutations in the BRCA 1 and 2 genes), but other less penetrant variants in genes involved in sporadic breast cancer have been described. These same genetic susceptibilities may be involved in negative radiotherapeutic outcomes. For these reasons, it is necessary to implement methods for detecting patients
who are susceptible to radiotherapy-related adverse events. This review discusses mechanisms of DNA damage
and repair, genes related to these functions, and the diagnosis methods designed and under research for detection of breast cancer patients with increased radiosensitivity. |
| format | Article |
| id | eprints-14941 |
| institution | UANL |
| language | English |
| publishDate | 2015 |
| record_format | eprints |
| spelling | eprints-149412020-09-30T01:10:22Z http://eprints.uanl.mx/14941/ Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer Borrego Soto, Gissela Ortiz López, Rocío Rojas Martínez, Augusto Breast cancer is the most common malignancy in women. Radiotherapy is frequently used in patients with breast cancer, but some patients may be more susceptible to ionizing radiation, and increased exposure to radiation sources may be associated to radiation adverse events. This susceptibility may be related to deficiencies in DNA repair mechanisms that are activated after cell-radiation, which causes DNA damage, particularly DNA double strand breaks. Some of these genetic susceptibilities in DNA-repair mechanisms are implicated in the etiology of hereditary breast/ovarian cancer (pathologic mutations in the BRCA 1 and 2 genes), but other less penetrant variants in genes involved in sporadic breast cancer have been described. These same genetic susceptibilities may be involved in negative radiotherapeutic outcomes. For these reasons, it is necessary to implement methods for detecting patients who are susceptible to radiotherapy-related adverse events. This review discusses mechanisms of DNA damage and repair, genes related to these functions, and the diagnosis methods designed and under research for detection of breast cancer patients with increased radiosensitivity. 2015 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14941/1/112.pdf http://eprints.uanl.mx/14941/1.haspreviewThumbnailVersion/112.pdf Borrego Soto, Gissela y Ortiz López, Rocío y Rojas Martínez, Augusto (2015) Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer. Genetics and molecular biology, 38 (4). pp. 420-432. ISSN 1415-4757 http://doi.org/10.1590/S1415-475738420150019 doi:10.1590/S1415-475738420150019 |
| spellingShingle | Borrego Soto, Gissela Ortiz López, Rocío Rojas Martínez, Augusto Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| title_full | Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| title_fullStr | Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| title_full_unstemmed | Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| title_short | Ionizing radiation-induced DNA injury and damage detection in patients with breast cancer |
| title_sort | ionizing radiation induced dna injury and damage detection in patients with breast cancer |
| url | http://eprints.uanl.mx/14941/1/112.pdf |
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