Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women
Background: A number of studies have demonstrated that receptor and co-receptor expression levels which may affect viral entry, promoting cervical HIV infection. The aim was to evaluate the expression levels of CCR5, CXCR4 and DC-SIGN mRNA in a sample of heterosexually HIV infected Mexican women. Me...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
2012
|
| Subjects: | |
| Online Access: | http://eprints.uanl.mx/14912/1/557.pdf |
| _version_ | 1824414185696526336 |
|---|---|
| author | Rivera Morales, Lydia Guadalupe López Guillén, Paulo Vázquez Guillén, José Manuel Palacios Saucedo, Gerardo del Carmen Rosas Taraco, Adrián Geovanni Ramírez Pineda, Antonio Amaya García, Patricia Irene Rodríguez Padilla, Cristina |
| author_facet | Rivera Morales, Lydia Guadalupe López Guillén, Paulo Vázquez Guillén, José Manuel Palacios Saucedo, Gerardo del Carmen Rosas Taraco, Adrián Geovanni Ramírez Pineda, Antonio Amaya García, Patricia Irene Rodríguez Padilla, Cristina |
| author_sort | Rivera Morales, Lydia Guadalupe |
| collection | Repositorio Institucional |
| description | Background: A number of studies have demonstrated that receptor and co-receptor expression levels which may affect viral entry, promoting cervical HIV infection. The aim was to evaluate the expression levels of CCR5, CXCR4 and DC-SIGN mRNA in a sample of heterosexually HIV infected Mexican women. Methods: We enrolled twenty-six HIV heterosexual infected women attending a local infectious diseases medical unit. RNA was isolated from the cervix and gene expression analysis was performed using real-time PCR. Results: Expression rates for mRNA of CCR5 (median 1.82; range 0.003–2934) were higher than those observed for CXCR4 (0.79; 0.0061–3312) and DC-SIGN (0.33; 0.006–532) receptors (p < 0.05). A high correlation was found between the mRNA expression levels of these three receptors (rs = 0.52 to 0.85, p < 0.01). Conclusion: Levels of expression of the tested chemokine receptors in the cervix are different from each other and also vary from woman to woman, and seem to support the suggestion that chemokine receptor expression in genital tissues may be playing a role in the HIV transmission. |
| format | Article |
| id | eprints-14912 |
| institution | UANL |
| language | English |
| publishDate | 2012 |
| record_format | eprints |
| spelling | eprints-149122020-06-24T16:57:01Z http://eprints.uanl.mx/14912/ Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women Rivera Morales, Lydia Guadalupe López Guillén, Paulo Vázquez Guillén, José Manuel Palacios Saucedo, Gerardo del Carmen Rosas Taraco, Adrián Geovanni Ramírez Pineda, Antonio Amaya García, Patricia Irene Rodríguez Padilla, Cristina QR Microbiología Background: A number of studies have demonstrated that receptor and co-receptor expression levels which may affect viral entry, promoting cervical HIV infection. The aim was to evaluate the expression levels of CCR5, CXCR4 and DC-SIGN mRNA in a sample of heterosexually HIV infected Mexican women. Methods: We enrolled twenty-six HIV heterosexual infected women attending a local infectious diseases medical unit. RNA was isolated from the cervix and gene expression analysis was performed using real-time PCR. Results: Expression rates for mRNA of CCR5 (median 1.82; range 0.003–2934) were higher than those observed for CXCR4 (0.79; 0.0061–3312) and DC-SIGN (0.33; 0.006–532) receptors (p < 0.05). A high correlation was found between the mRNA expression levels of these three receptors (rs = 0.52 to 0.85, p < 0.01). Conclusion: Levels of expression of the tested chemokine receptors in the cervix are different from each other and also vary from woman to woman, and seem to support the suggestion that chemokine receptor expression in genital tissues may be playing a role in the HIV transmission. 2012 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14912/1/557.pdf http://eprints.uanl.mx/14912/1.haspreviewThumbnailVersion/557.pdf Rivera Morales, Lydia Guadalupe y López Guillén, Paulo y Vázquez Guillén, José Manuel y Palacios Saucedo, Gerardo del Carmen y Rosas Taraco, Adrián Geovanni y Ramírez Pineda, Antonio y Amaya García, Patricia Irene y Rodríguez Padilla, Cristina (2012) Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women. The Open AIDS Journal, 6 (1). pp. 239-244. ISSN 18746136 http://doi.org/10.2174/1874613601206010239 doi:10.2174/1874613601206010239 |
| spellingShingle | QR Microbiología Rivera Morales, Lydia Guadalupe López Guillén, Paulo Vázquez Guillén, José Manuel Palacios Saucedo, Gerardo del Carmen Rosas Taraco, Adrián Geovanni Ramírez Pineda, Antonio Amaya García, Patricia Irene Rodríguez Padilla, Cristina Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| title_full | Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| title_fullStr | Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| title_full_unstemmed | Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| title_short | Expression of CCR5, CXCR4 and DC-SIGN in Cervix of HIV-1 Heterosexually Infected Mexican Women |
| title_sort | expression of ccr5 cxcr4 and dc sign in cervix of hiv 1 heterosexually infected mexican women |
| topic | QR Microbiología |
| url | http://eprints.uanl.mx/14912/1/557.pdf |
| work_keys_str_mv | AT riveramoraleslydiaguadalupe expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT lopezguillenpaulo expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT vazquezguillenjosemanuel expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT palaciossaucedogerardodelcarmen expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT rosastaracoadriangeovanni expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT ramirezpinedaantonio expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT amayagarciapatriciairene expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen AT rodriguezpadillacristina expressionofccr5cxcr4anddcsignincervixofhiv1heterosexuallyinfectedmexicanwomen |