The treatment of CML at an environment with limited resources
Objectives: This article reviews clinical experiences in the treatment of chronic myeloid leukemia (CML) in an environment of limited resources. Methods: We reviewed recent publications on Pub med and abstracts from mayor congresses relevant to the disease. Results: CML is a hematological neopla...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Acceso en línea: | http://eprints.uanl.mx/14875/1/83.pdf |
| _version_ | 1824414172537946112 |
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| author | Gómez Almaguer, David Cantú Rodríguez, Olga Graciela Gutiérrez Aguirre, César Homero Ruiz Argüelles, Guillermo José |
| author_facet | Gómez Almaguer, David Cantú Rodríguez, Olga Graciela Gutiérrez Aguirre, César Homero Ruiz Argüelles, Guillermo José |
| author_sort | Gómez Almaguer, David |
| collection | Repositorio Institucional |
| description | Objectives: This article reviews clinical experiences in the treatment of chronic myeloid leukemia (CML) in an
environment of limited resources.
Methods: We reviewed recent publications on Pub med and abstracts from mayor congresses relevant to the
disease.
Results: CML is a hematological neoplasm observed more frequently in adults, regardless of their
socioeconomic status. Until recently, available treatments improved patients’ quality of life but did not
modify survival. It was not until interferon appeared that patients received a drug that reduced and even
eliminated Philadelphia chromosome-positive (Ph+) cells.
Discussion: With the start of the new millennium, the International Randomized Study of Interferon-α plus
cytarabine versus STI571 (IRIS) trial demonstrated a dramatic improvement in survival by comparing
imatinib versus interferon alpha plus cytarabine. The Food and Drug Administration (FDA) approved
imatinib as first-line treatment for newly diagnosed CML in 2001 due to its outstanding effectiveness.
Years later, three second-generation (dasatinib, nilotinib, bosutinib) and one third-generation (ponatinib)
tyrosine-kinase inhibitors (TKIs) were developed and approved. These highly effective treatment options,
however, are not affordable for many low-income patients. Additionally, the use of drugs that effectively
treat but do not cure the disease has resulted in an important economic impact for patients and health
care systems worldwide, especially those in developing countries. Imatinib is the least expensive and a
very effective TKI in many low-income countries. Early allogeneic stem cell transplantation must be
considered in the management of selected patients before CML transformation. |
| format | Article |
| id | eprints-14875 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-148752020-06-08T22:26:29Z http://eprints.uanl.mx/14875/ The treatment of CML at an environment with limited resources Gómez Almaguer, David Cantú Rodríguez, Olga Graciela Gutiérrez Aguirre, César Homero Ruiz Argüelles, Guillermo José Objectives: This article reviews clinical experiences in the treatment of chronic myeloid leukemia (CML) in an environment of limited resources. Methods: We reviewed recent publications on Pub med and abstracts from mayor congresses relevant to the disease. Results: CML is a hematological neoplasm observed more frequently in adults, regardless of their socioeconomic status. Until recently, available treatments improved patients’ quality of life but did not modify survival. It was not until interferon appeared that patients received a drug that reduced and even eliminated Philadelphia chromosome-positive (Ph+) cells. Discussion: With the start of the new millennium, the International Randomized Study of Interferon-α plus cytarabine versus STI571 (IRIS) trial demonstrated a dramatic improvement in survival by comparing imatinib versus interferon alpha plus cytarabine. The Food and Drug Administration (FDA) approved imatinib as first-line treatment for newly diagnosed CML in 2001 due to its outstanding effectiveness. Years later, three second-generation (dasatinib, nilotinib, bosutinib) and one third-generation (ponatinib) tyrosine-kinase inhibitors (TKIs) were developed and approved. These highly effective treatment options, however, are not affordable for many low-income patients. Additionally, the use of drugs that effectively treat but do not cure the disease has resulted in an important economic impact for patients and health care systems worldwide, especially those in developing countries. Imatinib is the least expensive and a very effective TKI in many low-income countries. Early allogeneic stem cell transplantation must be considered in the management of selected patients before CML transformation. 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14875/1/83.pdf http://eprints.uanl.mx/14875/1.haspreviewThumbnailVersion/83.pdf Gómez Almaguer, David y Cantú Rodríguez, Olga Graciela y Gutiérrez Aguirre, César Homero y Ruiz Argüelles, Guillermo José (2016) The treatment of CML at an environment with limited resources. Hematology, 21 (10). pp. 576-582. ISSN 1024-5332 http://doi.org/10.1080/10245332.2016.1182695 doi:10.1080/10245332.2016.1182695 |
| spellingShingle | Gómez Almaguer, David Cantú Rodríguez, Olga Graciela Gutiérrez Aguirre, César Homero Ruiz Argüelles, Guillermo José The treatment of CML at an environment with limited resources |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | The treatment of CML at an environment with limited resources |
| title_full | The treatment of CML at an environment with limited resources |
| title_fullStr | The treatment of CML at an environment with limited resources |
| title_full_unstemmed | The treatment of CML at an environment with limited resources |
| title_short | The treatment of CML at an environment with limited resources |
| title_sort | treatment of cml at an environment with limited resources |
| url | http://eprints.uanl.mx/14875/1/83.pdf |
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