In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil
Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDL...
| Autores principales: | , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2016
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| Acceso en línea: | http://eprints.uanl.mx/14873/1/81.pdf |
| _version_ | 1824414171768291328 |
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| author | Coronado Cerda, Erika Evangelina Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Prado García, Heriberto Rivera Morales, Lydia Guadalupe Zapata Benavides, Pablo Rodríguez Salazar, María del Carmen Caballero Hernández, Diana Elia Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina |
| author_facet | Coronado Cerda, Erika Evangelina Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Prado García, Heriberto Rivera Morales, Lydia Guadalupe Zapata Benavides, Pablo Rodríguez Salazar, María del Carmen Caballero Hernández, Diana Elia Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina |
| author_sort | Coronado Cerda, Erika Evangelina |
| collection | Repositorio Institucional |
| description | Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells
in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed. Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1
phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice. These results suggest that ICRP has
a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients. |
| format | Article |
| id | eprints-14873 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| record_format | eprints |
| spelling | eprints-148732019-05-24T15:27:47Z http://eprints.uanl.mx/14873/ In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil Coronado Cerda, Erika Evangelina Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Prado García, Heriberto Rivera Morales, Lydia Guadalupe Zapata Benavides, Pablo Rodríguez Salazar, María del Carmen Caballero Hernández, Diana Elia Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina Chemotherapy treatments induce a number of side effects, such as leukopenia neutropenia, peripheral erythropenia, and thrombocytopenia, affecting the quality of life for cancer patients. 5-Fluorouracil (5-FU) is wieldy used as myeloablative model in mice. The bovine dialyzable leukocyte extract (bDLE) or IMMUNEPOTENT CRP (ICRP) is an immunomodulatory compound that has antioxidants and anti-inflammatory effects. In order to investigate the chemoprotection effect of ICRP on bone marrow cells in 5-FU treated mice, total bone marrow (BM) cell count, bone marrow colony forming units-granulocyte/macrophage (CFU-GM), cell cycle, immunophenotypification, ROS/superoxide and Nrf2 by flow cytometry, and histological and hematological analyses were performed. Our results demonstrated that ICRP increased BM cell count and CFU-GM number, arrested BM cells in G0/G1 phase, increased the percentage of leukocyte, granulocytic, and erythroid populations, reduced ROS/superoxide formation and Nrf2 activation, and also improved hematological levels and weight gain in 5-FU treated mice. These results suggest that ICRP has a chemoprotective effect against 5-FU in BM cells that can be used in cancer patients. 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14873/1/81.pdf http://eprints.uanl.mx/14873/1.haspreviewThumbnailVersion/81.pdf Coronado Cerda, Erika Evangelina y Franco Molina, Moisés Armides y Mendoza Gamboa, Edgar y Prado García, Heriberto y Rivera Morales, Lydia Guadalupe y Zapata Benavides, Pablo y Rodríguez Salazar, María del Carmen y Caballero Hernández, Diana Elia y Tamez Guerra, Reyes Silvestre y Rodríguez Padilla, Cristina (2016) In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil. Journal of Immunology Research, 2016. pp. 1-10. ISSN 2314-8861 http://doi.org/10.1155/2016/6942321 doi:10.1155/2016/6942321 |
| spellingShingle | Coronado Cerda, Erika Evangelina Franco Molina, Moisés Armides Mendoza Gamboa, Edgar Prado García, Heriberto Rivera Morales, Lydia Guadalupe Zapata Benavides, Pablo Rodríguez Salazar, María del Carmen Caballero Hernández, Diana Elia Tamez Guerra, Reyes Silvestre Rodríguez Padilla, Cristina In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| title_full | In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| title_fullStr | In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| title_full_unstemmed | In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| title_short | In VivoChemoprotective Activity of Bovine Dialyzable Leukocyte Extract in Mouse Bone Marrow Cells against Damage Induced by 5-Fluorouracil |
| title_sort | in vivochemoprotective activity of bovine dialyzable leukocyte extract in mouse bone marrow cells against damage induced by 5 fluorouracil |
| url | http://eprints.uanl.mx/14873/1/81.pdf |
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