Hepatogenous diabetes: Is it a neglected condition in chronic liver disease?
Diabetes mellitus (DM) that occurs because of chronic liver disease (CLD) is known as hepatogenous diabetes (HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low freque...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
WJG Press
2016
|
| Acceso en línea: | http://eprints.uanl.mx/14830/1/47.pdf |
| _version_ | 1824414155372756992 |
|---|---|
| author | García Compeán, Diego González González, José Alberto Lavalle González, Fernando Javier González Moreno, Emmanuel Irineo Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús |
| author_facet | García Compeán, Diego González González, José Alberto Lavalle González, Fernando Javier González Moreno, Emmanuel Irineo Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús |
| author_sort | García Compeán, Diego |
| collection | Repositorio Institucional |
| description | Diabetes mellitus (DM) that occurs because of chronic
liver disease (CLD) is known as hepatogenous diabetes
(HD). Although the association of diabetes and liver
cirrhosis was described forty years ago, it was scarcely
studied for long time. Patients suffering from this
condition have low frequency of risk factors of type
2 DM. Its incidence is higher in CLD of viral, alcoholic
and cryptogenic etiology. Its pathophysiology relates
to liver damage, pancreatic dysfunction, interactions
between hepatitis C virus (HCV) and glucose metabolism
mechanisms and genetic susceptibility. It
associates with increased rate of liver complications
and hepatocellular carcinoma, and decreased 5-year
survival rate. It reduces sustained virological response
in HCV infected patients. In spite of these evidences,
the American Diabetes Association does not recognize
HD. In addition, the impact of glucose control on
clinical outcomes of patients has not been evaluated.
Treatment of diabetes may be difficult due to liver
insufficiency and hepatotoxicity of antidiabetic drugs.
Notwithstanding, no therapeutic guidelines have been
implemented up to date. In this editorial, authors
discuss the reasons why they think that HD may be a
neglected pathological condition and call attention to
the necessity for more clinical research on different
fields of this disease. |
| format | Article |
| id | eprints-14830 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| publisher | WJG Press |
| record_format | eprints |
| spelling | eprints-148302024-03-05T15:36:52Z http://eprints.uanl.mx/14830/ Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? García Compeán, Diego González González, José Alberto Lavalle González, Fernando Javier González Moreno, Emmanuel Irineo Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús Diabetes mellitus (DM) that occurs because of chronic liver disease (CLD) is known as hepatogenous diabetes (HD). Although the association of diabetes and liver cirrhosis was described forty years ago, it was scarcely studied for long time. Patients suffering from this condition have low frequency of risk factors of type 2 DM. Its incidence is higher in CLD of viral, alcoholic and cryptogenic etiology. Its pathophysiology relates to liver damage, pancreatic dysfunction, interactions between hepatitis C virus (HCV) and glucose metabolism mechanisms and genetic susceptibility. It associates with increased rate of liver complications and hepatocellular carcinoma, and decreased 5-year survival rate. It reduces sustained virological response in HCV infected patients. In spite of these evidences, the American Diabetes Association does not recognize HD. In addition, the impact of glucose control on clinical outcomes of patients has not been evaluated. Treatment of diabetes may be difficult due to liver insufficiency and hepatotoxicity of antidiabetic drugs. Notwithstanding, no therapeutic guidelines have been implemented up to date. In this editorial, authors discuss the reasons why they think that HD may be a neglected pathological condition and call attention to the necessity for more clinical research on different fields of this disease. WJG Press 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14830/1/47.pdf http://eprints.uanl.mx/14830/1.haspreviewThumbnailVersion/47.pdf García Compeán, Diego y González González, José Alberto y Lavalle González, Fernando Javier y González Moreno, Emmanuel Irineo y Villarreal Pérez, Jesús Zacarías y Maldonado Garza, Héctor Jesús (2016) Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? World journal of gastroenterology, 22 (10). p. 2869. ISSN 1007-9327 http://doi.org/10.3748/wjg.v22.i10.2869 doi:10.3748/wjg.v22.i10.2869 |
| spellingShingle | García Compeán, Diego González González, José Alberto Lavalle González, Fernando Javier González Moreno, Emmanuel Irineo Villarreal Pérez, Jesús Zacarías Maldonado Garza, Héctor Jesús Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| title_full | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| title_fullStr | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| title_full_unstemmed | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| title_short | Hepatogenous diabetes: Is it a neglected condition in chronic liver disease? |
| title_sort | hepatogenous diabetes is it a neglected condition in chronic liver disease |
| url | http://eprints.uanl.mx/14830/1/47.pdf |
| work_keys_str_mv | AT garciacompeandiego hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease AT gonzalezgonzalezjosealberto hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease AT lavallegonzalezfernandojavier hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease AT gonzalezmorenoemmanuelirineo hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease AT villarrealperezjesuszacarias hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease AT maldonadogarzahectorjesus hepatogenousdiabetesisitaneglectedconditioninchronicliverdisease |