Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats
Background: The antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. Objectives: The present study evaluated the protective effect of arbutin against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Sixty-three Wistar rats were divided into n...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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2013
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| Online Access: | http://eprints.uanl.mx/14687/1/425.pdf |
| _version_ | 1824414113059569664 |
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| author | Cordero Pérez, Paula Aguirre Garza, Marcelino Camara Lemarroy, Carlos Rodrigo Alarcón Galván, Gabriela Cantú Sepúlveda, Daniel Bernal Ramirez, Judith Torres González, Liliana Guzmán de la Garza, Francisco Javier Zapata Chavira, Homero Sotelo Gallegos, Ma. de Jesús Torres Esquivel, CipactliNadjedja Sánchez Fresno, Ethel Corinthia González Saldívar, Gerardo Muñoz Espinosa, Linda Elsa |
| author_facet | Cordero Pérez, Paula Aguirre Garza, Marcelino Camara Lemarroy, Carlos Rodrigo Alarcón Galván, Gabriela Cantú Sepúlveda, Daniel Bernal Ramirez, Judith Torres González, Liliana Guzmán de la Garza, Francisco Javier Zapata Chavira, Homero Sotelo Gallegos, Ma. de Jesús Torres Esquivel, CipactliNadjedja Sánchez Fresno, Ethel Corinthia González Saldívar, Gerardo Muñoz Espinosa, Linda Elsa |
| author_sort | Cordero Pérez, Paula |
| collection | Repositorio Institucional |
| description | Background: The antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. Objectives: The present study evaluated the protective effect of arbutin against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Sixty-three Wistar rats were divided into nine groups. Groups I and II were the normal control groups. Group III, the hepatotoxic group, was given CCl4. Groups IV, VI, and VIII received different dosages of arbutin along with CCl4. Groups V, VII, and IX were administered different dosages of arbutin. The albumin content, total protein, and bilirubin were assayed to determine their serum and antioxidant levels; lipid peroxidation was assessed in the serum and liver tissue. Histological studies were carried out to confirm the biochemical results. Results: Treatment with CCl4 for 28 d decreased the levels of total protein and albumin and increased the level of bilirubin and lipid peroxidation. Arbutin treatment raised the level of albumin and lowered the lipid peroxidation to normal levels. Necrosis and fibrosis were observed in the liver tissue of CCl4-injected rats, and the administration of arbutin had a protective effect on the liver tissue. Conclusions: The results of this study showed that arbutin may protect the liver against CCl4-induced oxidative damage in rats. This hepatoprotective effect might be correlated with the antioxidant and free radical scavenger effects of arbutin. |
| format | Article |
| id | eprints-14687 |
| institution | UANL |
| language | English |
| publishDate | 2013 |
| record_format | eprints |
| spelling | eprints-146872021-11-05T19:57:54Z http://eprints.uanl.mx/14687/ Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats Cordero Pérez, Paula Aguirre Garza, Marcelino Camara Lemarroy, Carlos Rodrigo Alarcón Galván, Gabriela Cantú Sepúlveda, Daniel Bernal Ramirez, Judith Torres González, Liliana Guzmán de la Garza, Francisco Javier Zapata Chavira, Homero Sotelo Gallegos, Ma. de Jesús Torres Esquivel, CipactliNadjedja Sánchez Fresno, Ethel Corinthia González Saldívar, Gerardo Muñoz Espinosa, Linda Elsa Background: The antioxidant and anti-inflammatory effects of arbutin protect against a number of diseases. Objectives: The present study evaluated the protective effect of arbutin against carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Methods: Sixty-three Wistar rats were divided into nine groups. Groups I and II were the normal control groups. Group III, the hepatotoxic group, was given CCl4. Groups IV, VI, and VIII received different dosages of arbutin along with CCl4. Groups V, VII, and IX were administered different dosages of arbutin. The albumin content, total protein, and bilirubin were assayed to determine their serum and antioxidant levels; lipid peroxidation was assessed in the serum and liver tissue. Histological studies were carried out to confirm the biochemical results. Results: Treatment with CCl4 for 28 d decreased the levels of total protein and albumin and increased the level of bilirubin and lipid peroxidation. Arbutin treatment raised the level of albumin and lowered the lipid peroxidation to normal levels. Necrosis and fibrosis were observed in the liver tissue of CCl4-injected rats, and the administration of arbutin had a protective effect on the liver tissue. Conclusions: The results of this study showed that arbutin may protect the liver against CCl4-induced oxidative damage in rats. This hepatoprotective effect might be correlated with the antioxidant and free radical scavenger effects of arbutin. 2013 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14687/1/425.pdf http://eprints.uanl.mx/14687/1.haspreviewThumbnailVersion/425.pdf Cordero Pérez, Paula y Aguirre Garza, Marcelino y Camara Lemarroy, Carlos Rodrigo y Alarcón Galván, Gabriela y Cantú Sepúlveda, Daniel y Bernal Ramirez, Judith y Torres González, Liliana y Guzmán de la Garza, Francisco Javier y Zapata Chavira, Homero y Sotelo Gallegos, Ma. de Jesús y Torres Esquivel, CipactliNadjedja y Sánchez Fresno, Ethel Corinthia y González Saldívar, Gerardo y Muñoz Espinosa, Linda Elsa (2013) Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats. Pharmacognosy Research, 5 (3). p. 150. ISSN 0974-8490 http://doi.org/10.4103/0974-8490.112417 doi:10.4103/0974-8490.112417 |
| spellingShingle | Cordero Pérez, Paula Aguirre Garza, Marcelino Camara Lemarroy, Carlos Rodrigo Alarcón Galván, Gabriela Cantú Sepúlveda, Daniel Bernal Ramirez, Judith Torres González, Liliana Guzmán de la Garza, Francisco Javier Zapata Chavira, Homero Sotelo Gallegos, Ma. de Jesús Torres Esquivel, CipactliNadjedja Sánchez Fresno, Ethel Corinthia González Saldívar, Gerardo Muñoz Espinosa, Linda Elsa Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| title_full | Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| title_fullStr | Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| title_full_unstemmed | Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| title_short | Hepatoprotective effect of commercial herbal extracts on carbon tetrachloride-induced liver damage in Wistar rats |
| title_sort | hepatoprotective effect of commercial herbal extracts on carbon tetrachloride induced liver damage in wistar rats |
| url | http://eprints.uanl.mx/14687/1/425.pdf |
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