Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome
Background: There have been antidiabetic claims for Aloe vera (AG) Barbadensis Mill. gel and infusion of Cnidoscolus chayamansa (CC) McVaugh. Objectives: To determine if the ingestion of total process AG concentrated 5:1 (TA), AG, CC or placebo can reduce hyperglycemia in women with early metabolic...
| Autores principales: | , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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Elsevier Health Sciences
2017
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/14519/1/31.pdf |
| _version_ | 1838550984836513792 |
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| author | Cárdenas Ibarra, Lilia Villarreal Pérez, Jesús Zacarías Lira Castillo, J. Carlos Nava Alemán, Aram |
| author_facet | Cárdenas Ibarra, Lilia Villarreal Pérez, Jesús Zacarías Lira Castillo, J. Carlos Nava Alemán, Aram |
| author_sort | Cárdenas Ibarra, Lilia |
| collection | Repositorio Institucional |
| description | Background: There have been antidiabetic claims for Aloe vera (AG) Barbadensis Mill. gel and infusion of Cnidoscolus chayamansa (CC) McVaugh. Objectives: To determine if the ingestion of total process AG concentrated 5:1 (TA), AG, CC or placebo can reduce hyperglycemia in women with early metabolic syndrome (EMS). Methods: One hundred-twenty five women from two outpatient university clinics were randomly assigned to a three assay doubleblind crossover procedure. Subjects were adult women with EMS by ATP III criteria assigned to assay 1: AG&CC vs P1&P2; assay 2: AG&P2 vs P1&CC; or assay 3: TA vs P3. All assays included the ingestion of one, then zero (washout period), then two gelatins/day, for 4, 1, 4 weeks, respectively. The expected outcome was an HbA1c decrease ≥4.2 mmol/mol or lower but sustaining euglycemia. Results: Participants had a mean age of 46.8 ± 9.7 years and a mean HbA1c of 47.8 ± 12.7 mmol/mol at the start of the study. The least tolerated combination was AG&P2. Patients complained of bad taste and mild stomach pain because of the double dose of this treatment; this caused withdrawals: 4/25 vs. 9/21, respectively, Chi square ¼ 4.1, df ¼ 1, P < 0.05. Changes in HbA1c (mmol/mol) were assay 1, 1.8 ± 7.5 vs 1.6 ± 6.9, P > 0.05; assay 2, 1.3 ± 6.6 vs 1.4 ± 7.6, P > 0.05; assay 3, 4.9 ± 8.3 vs 0.44 ± 5.4, P < 0.01, respectively. TA concomitantly reduced high-sensitive C-reactive
protein (hs-CRP) (P < 0.05). Conclusions: Data suggest that TA decreases blood glucose levels by reducing the proinflammatory state. The infusion of microwave dehydrated CC leaves did not reduce blood glucose or HDL and triglyceride levels. |
| format | Article |
| id | eprints-14519 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| publisher | Elsevier Health Sciences |
| record_format | eprints |
| spelling | eprints-145192025-07-10T16:16:33Z http://eprints.uanl.mx/14519/ Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome Cárdenas Ibarra, Lilia Villarreal Pérez, Jesús Zacarías Lira Castillo, J. Carlos Nava Alemán, Aram RM Terapéutica, Farmacología Background: There have been antidiabetic claims for Aloe vera (AG) Barbadensis Mill. gel and infusion of Cnidoscolus chayamansa (CC) McVaugh. Objectives: To determine if the ingestion of total process AG concentrated 5:1 (TA), AG, CC or placebo can reduce hyperglycemia in women with early metabolic syndrome (EMS). Methods: One hundred-twenty five women from two outpatient university clinics were randomly assigned to a three assay doubleblind crossover procedure. Subjects were adult women with EMS by ATP III criteria assigned to assay 1: AG&CC vs P1&P2; assay 2: AG&P2 vs P1&CC; or assay 3: TA vs P3. All assays included the ingestion of one, then zero (washout period), then two gelatins/day, for 4, 1, 4 weeks, respectively. The expected outcome was an HbA1c decrease ≥4.2 mmol/mol or lower but sustaining euglycemia. Results: Participants had a mean age of 46.8 ± 9.7 years and a mean HbA1c of 47.8 ± 12.7 mmol/mol at the start of the study. The least tolerated combination was AG&P2. Patients complained of bad taste and mild stomach pain because of the double dose of this treatment; this caused withdrawals: 4/25 vs. 9/21, respectively, Chi square ¼ 4.1, df ¼ 1, P < 0.05. Changes in HbA1c (mmol/mol) were assay 1, 1.8 ± 7.5 vs 1.6 ± 6.9, P > 0.05; assay 2, 1.3 ± 6.6 vs 1.4 ± 7.6, P > 0.05; assay 3, 4.9 ± 8.3 vs 0.44 ± 5.4, P < 0.01, respectively. TA concomitantly reduced high-sensitive C-reactive protein (hs-CRP) (P < 0.05). Conclusions: Data suggest that TA decreases blood glucose levels by reducing the proinflammatory state. The infusion of microwave dehydrated CC leaves did not reduce blood glucose or HDL and triglyceride levels. Elsevier Health Sciences 2017 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14519/1/31.pdf http://eprints.uanl.mx/14519/1.haspreviewThumbnailVersion/31.pdf Cárdenas Ibarra, Lilia y Villarreal Pérez, Jesús Zacarías y Lira Castillo, J. Carlos y Nava Alemán, Aram (2017) Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome. Clinical nutrition experimental, 14. pp. 1-12. ISSN 23529393 http://doi.org/10.1016/j.yclnex.2017.05.003 doi:10.1016/j.yclnex.2017.05.003 |
| spellingShingle | RM Terapéutica, Farmacología Cárdenas Ibarra, Lilia Villarreal Pérez, Jesús Zacarías Lira Castillo, J. Carlos Nava Alemán, Aram Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| title_full | Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| title_fullStr | Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| title_full_unstemmed | Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| title_short | Randomized double blind crossover trial of Aloe vera , Cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| title_sort | randomized double blind crossover trial of aloe vera cnidoscolus chayamansa and placebo for reducing hyperglycemia in women with early metabolic syndrome |
| topic | RM Terapéutica, Farmacología |
| url | http://eprints.uanl.mx/14519/1/31.pdf |
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