Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013
The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N...
| Autores principales: | , , , , , , , , , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
| Publicado: |
2017
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/14499/1/12.pdf |
| _version_ | 1824414063616065536 |
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| author | Swerdlow, David L. Canche Pech, Jose Reyes Conde Ferraez, Laura Puerto Solis, Marylin Gonzalez Losa, Refugio Granja Pérez, Pilar Villanueva Jorge, Salha Chan Gasca, Maria Gómez Carballo, Jesús López Ochoa, Luisa Jiménez Delgadillo, Bertha Rodríguez Sánchez, Irám Pablo Ramírez Prado, Jorge Ayora Talavera, Guadalupe |
| author_facet | Swerdlow, David L. Canche Pech, Jose Reyes Conde Ferraez, Laura Puerto Solis, Marylin Gonzalez Losa, Refugio Granja Pérez, Pilar Villanueva Jorge, Salha Chan Gasca, Maria Gómez Carballo, Jesús López Ochoa, Luisa Jiménez Delgadillo, Bertha Rodríguez Sánchez, Irám Pablo Ramírez Prado, Jorge Ayora Talavera, Guadalupe |
| author_sort | Swerdlow, David L. |
| collection | Repositorio Institucional |
| description | The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NAL206S circulated in August and September. We discuss the significance of these novel genetic changes. |
| format | Article |
| id | eprints-14499 |
| institution | UANL |
| language | English |
| publishDate | 2017 |
| record_format | eprints |
| spelling | eprints-144992023-05-24T20:27:58Z http://eprints.uanl.mx/14499/ Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 Swerdlow, David L. Canche Pech, Jose Reyes Conde Ferraez, Laura Puerto Solis, Marylin Gonzalez Losa, Refugio Granja Pérez, Pilar Villanueva Jorge, Salha Chan Gasca, Maria Gómez Carballo, Jesús López Ochoa, Luisa Jiménez Delgadillo, Bertha Rodríguez Sánchez, Irám Pablo Ramírez Prado, Jorge Ayora Talavera, Guadalupe RA Aspectos Públicos de la Medicina The 2012 and 2013 annual influenza epidemics in Mexico were characterized by presenting different seasonal patterns. In 2012 the A(H1N1)pdm09 virus caused a high incidence of influenza infections after a two-year period of low circulation; whereas the 2013 epidemic presented circulation of the A(H1N1)pdm09 virus throughout the year. We have characterized the molecular composition of the Hemagglutinin (HA) and Neuraminidase (NA) genes of the A(H1N1)pdm09 virus from both epidemic seasons, emphasizing the genetic characteristics of viruses isolated from Yucatan in Southern Mexico. The molecular analysis of viruses from the 2012 revealed that all viruses from Mexico were predominantly grouped in clade 7. Strikingly, the molecular characterization of viruses from 2013 revealed that viruses circulating in Yucatan were genetically different to viruses from other regions of Mexico. In fact, we identified the occurrence of two genetic variants containing relevant mutations at both the HA and NA surface antigens. There was a difference on the temporal circulation of each genetic variant, viruses containing the mutations HA-A141T / NA-N341S were detected in May, June and July; whereas viruses containing the mutations HA-S162I / NAL206S circulated in August and September. We discuss the significance of these novel genetic changes. 2017 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/14499/1/12.pdf http://eprints.uanl.mx/14499/1.haspreviewThumbnailVersion/12.pdf Swerdlow, David L. y Canche Pech, Jose Reyes y Conde Ferraez, Laura y Puerto Solis, Marylin y Gonzalez Losa, Refugio y Granja Pérez, Pilar y Villanueva Jorge, Salha y Chan Gasca, Maria y Gómez Carballo, Jesús y López Ochoa, Luisa y Jiménez Delgadillo, Bertha y Rodríguez Sánchez, Irám Pablo y Ramírez Prado, Jorge y Ayora Talavera, Guadalupe (2017) Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013. PLOS ONE, 12 (12). e0189363. ISSN 1932-6203 http://doi.org/10.1371/journal.pone.0189363 doi:10.1371/journal.pone.0189363 |
| spellingShingle | RA Aspectos Públicos de la Medicina Swerdlow, David L. Canche Pech, Jose Reyes Conde Ferraez, Laura Puerto Solis, Marylin Gonzalez Losa, Refugio Granja Pérez, Pilar Villanueva Jorge, Salha Chan Gasca, Maria Gómez Carballo, Jesús López Ochoa, Luisa Jiménez Delgadillo, Bertha Rodríguez Sánchez, Irám Pablo Ramírez Prado, Jorge Ayora Talavera, Guadalupe Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| title_full | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| title_fullStr | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| title_full_unstemmed | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| title_short | Temporal distribution and genetic variants in influenza A(H1N1)pdm09 virus circulating in Mexico, seasons 2012 and 2013 |
| title_sort | temporal distribution and genetic variants in influenza a h1n1 pdm09 virus circulating in mexico seasons 2012 and 2013 |
| topic | RA Aspectos Públicos de la Medicina |
| url | http://eprints.uanl.mx/14499/1/12.pdf |
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