Exercise-induced adaptations of rat soleus muscle grafts

In female Wistar rats (n = 316) under pentobarbital sodium anesthesia, the soleus muscle was autografted with its nerve reimplanted. One purpose was to characterize the chronological development of graft innervation and recruitment during locomotion. Furthermore, we tested hypotheses regarding the e...

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Autores principales: White, Timothy P., Villanacci, John F., Morales, Pedro G., Segal, Steven S., Essig, David A.
Formato: Artículo
Lenguaje:inglés
Publicado: University of Michigan 1983
Materias:
Acceso en línea:http://eprints.uanl.mx/13257/1/Art.%202.pdf
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author White, Timothy P.
Villanacci, John F.
Morales, Pedro G.
Segal, Steven S.
Essig, David A.
author_facet White, Timothy P.
Villanacci, John F.
Morales, Pedro G.
Segal, Steven S.
Essig, David A.
author_sort White, Timothy P.
collection Repositorio Institucional
description In female Wistar rats (n = 316) under pentobarbital sodium anesthesia, the soleus muscle was autografted with its nerve reimplanted. One purpose was to characterize the chronological development of graft innervation and recruitment during locomotion. Furthermore, we tested hypotheses regarding the efficacy of run conditioning of different intensities, durations, and postgrafting initiation times to alter mass and pyruvate-malate oxidation capacity of grafts. Choline acetyltransferase activity of grafts increased from 10% of control value at 7 days postgrafting to 55 and 100% at days 28 and 56, respectively. Running-induced glycogen depletion occurred in grafts; this is consistent with graft recruitment during locomotion. There was a threshold of conditioning intensity below which no improvements occurred and above which there were improvements. Spring (50 m/min) and endurance (30 m/min) conditioning of a duration of at least 28 days that was initiated at 28 or 56 days postgrafting increased mass of grafts by 30% compared with grafts from nonconditioned rats. Easy conditioning (15 m/min) had no effect on graft mass. Changes in graft total protein content paralleled those of mass. Oxidation capacity of grafts increased significantly with some conditioning protocols, but not to the same extent as mass. The exercise-induced adaptations should improve graft function in the host organism.
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spelling eprints-132572018-10-22T20:16:30Z http://eprints.uanl.mx/13257/ Exercise-induced adaptations of rat soleus muscle grafts White, Timothy P. Villanacci, John F. Morales, Pedro G. Segal, Steven S. Essig, David A. GV Deportes y Recreación In female Wistar rats (n = 316) under pentobarbital sodium anesthesia, the soleus muscle was autografted with its nerve reimplanted. One purpose was to characterize the chronological development of graft innervation and recruitment during locomotion. Furthermore, we tested hypotheses regarding the efficacy of run conditioning of different intensities, durations, and postgrafting initiation times to alter mass and pyruvate-malate oxidation capacity of grafts. Choline acetyltransferase activity of grafts increased from 10% of control value at 7 days postgrafting to 55 and 100% at days 28 and 56, respectively. Running-induced glycogen depletion occurred in grafts; this is consistent with graft recruitment during locomotion. There was a threshold of conditioning intensity below which no improvements occurred and above which there were improvements. Spring (50 m/min) and endurance (30 m/min) conditioning of a duration of at least 28 days that was initiated at 28 or 56 days postgrafting increased mass of grafts by 30% compared with grafts from nonconditioned rats. Easy conditioning (15 m/min) had no effect on graft mass. Changes in graft total protein content paralleled those of mass. Oxidation capacity of grafts increased significantly with some conditioning protocols, but not to the same extent as mass. The exercise-induced adaptations should improve graft function in the host organism. University of Michigan 1983 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/13257/1/Art.%202.pdf http://eprints.uanl.mx/13257/1.haspreviewThumbnailVersion/Art.%202.pdf White, Timothy P. y Villanacci, John F. y Morales, Pedro G. y Segal, Steven S. y Essig, David A. (1983) Exercise-induced adaptations of rat soleus muscle grafts. Journal of Applied Physiology,, 56 (5). pp. 1325-1334. ISSN 48109-2214
spellingShingle GV Deportes y Recreación
White, Timothy P.
Villanacci, John F.
Morales, Pedro G.
Segal, Steven S.
Essig, David A.
Exercise-induced adaptations of rat soleus muscle grafts
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Exercise-induced adaptations of rat soleus muscle grafts
title_full Exercise-induced adaptations of rat soleus muscle grafts
title_fullStr Exercise-induced adaptations of rat soleus muscle grafts
title_full_unstemmed Exercise-induced adaptations of rat soleus muscle grafts
title_short Exercise-induced adaptations of rat soleus muscle grafts
title_sort exercise induced adaptations of rat soleus muscle grafts
topic GV Deportes y Recreación
url http://eprints.uanl.mx/13257/1/Art.%202.pdf
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