Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis
Several models of chronic obstructive pulmonary disease (COPD) in mice have been developed; the most similar to the habit of smoking is the inhalation of the smoke in mice. The objective was to develop and implement an experimental model of COPD in mice through the passive inhalation of smoke and d...
| Autores principales: | , , , , , |
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| Formato: | Artículo |
| Lenguaje: | inglés |
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UANL. Facultad de Medicina
2016
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| Materias: | |
| Acceso en línea: | http://eprints.uanl.mx/11730/1/S1665579616300606_S300_en.pdf |
| _version_ | 1824413435412086784 |
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| author | Reyna Sepúlveda, Francisco J. Caballero Mendoza, E. Guzmán de la Garza, Francisco Javier Fernández Garza, Nancy Esthela Muñoz Maldonado, Gerardo Enrique Ancer Rodríguez, Jesús |
| author_facet | Reyna Sepúlveda, Francisco J. Caballero Mendoza, E. Guzmán de la Garza, Francisco Javier Fernández Garza, Nancy Esthela Muñoz Maldonado, Gerardo Enrique Ancer Rodríguez, Jesús |
| author_sort | Reyna Sepúlveda, Francisco J. |
| collection | Repositorio Institucional |
| description | Several models of chronic obstructive pulmonary disease (COPD) in mice have been developed; the most similar to the habit of smoking is the inhalation of the smoke
in mice. The objective was to develop and implement an experimental model of COPD in mice through the passive inhalation of smoke and demonstrate the physiological changes on ventilatory function and its correlation with 3 emphysema quantification methods. Materials and methods: Twenty Wistar mice were included in an experimental and control group. The experimental group was exposed to tobacco smoke, and we performed several
pulmonary functional tests and imaging techniques.
Results: Pulmonary function tests showed the volume expiration in the first second (VEF1) differs significantly between groups (p < 0.001). Pulmonary compliance was reduced in the experimental group by 50% in comparison to the control group (male vs control p < 0.001). Morphometric analysis: 17% reduction in lung volume with a destructive index (DI) of 45%. The
intersection test had a DI of 43%. The free point test showed a DI of 44%. Conclusions: The implementation of our model generated the presence of emphysema and
alterations in the lung physiology in the experimental group. We demonstrated evidence of 90% with emphysema |
| format | Article |
| id | eprints-11730 |
| institution | UANL |
| language | English |
| publishDate | 2016 |
| publisher | UANL. Facultad de Medicina |
| record_format | eprints |
| spelling | eprints-117302024-03-05T20:47:02Z http://eprints.uanl.mx/11730/ Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis Reyna Sepúlveda, Francisco J. Caballero Mendoza, E. Guzmán de la Garza, Francisco Javier Fernández Garza, Nancy Esthela Muñoz Maldonado, Gerardo Enrique Ancer Rodríguez, Jesús RC Medicina Interna, Psiquiatría, Neurología Several models of chronic obstructive pulmonary disease (COPD) in mice have been developed; the most similar to the habit of smoking is the inhalation of the smoke in mice. The objective was to develop and implement an experimental model of COPD in mice through the passive inhalation of smoke and demonstrate the physiological changes on ventilatory function and its correlation with 3 emphysema quantification methods. Materials and methods: Twenty Wistar mice were included in an experimental and control group. The experimental group was exposed to tobacco smoke, and we performed several pulmonary functional tests and imaging techniques. Results: Pulmonary function tests showed the volume expiration in the first second (VEF1) differs significantly between groups (p < 0.001). Pulmonary compliance was reduced in the experimental group by 50% in comparison to the control group (male vs control p < 0.001). Morphometric analysis: 17% reduction in lung volume with a destructive index (DI) of 45%. The intersection test had a DI of 43%. The free point test showed a DI of 44%. Conclusions: The implementation of our model generated the presence of emphysema and alterations in the lung physiology in the experimental group. We demonstrated evidence of 90% with emphysema UANL. Facultad de Medicina 2016 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/11730/1/S1665579616300606_S300_en.pdf http://eprints.uanl.mx/11730/1.haspreviewThumbnailVersion/S1665579616300606_S300_en.pdf Reyna Sepúlveda, Francisco J. y Caballero Mendoza, E. y Guzmán de la Garza, Francisco Javier y Fernández Garza, Nancy Esthela y Muñoz Maldonado, Gerardo Enrique y Ancer Rodríguez, Jesús (2016) Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis. Medicina universitaria, 18 (71). pp. 79-84. ISSN 1665-5796 |
| spellingShingle | RC Medicina Interna, Psiquiatría, Neurología Reyna Sepúlveda, Francisco J. Caballero Mendoza, E. Guzmán de la Garza, Francisco Javier Fernández Garza, Nancy Esthela Muñoz Maldonado, Gerardo Enrique Ancer Rodríguez, Jesús Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| title_full | Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| title_fullStr | Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| title_full_unstemmed | Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| title_short | Emphysema model in rats exposed to tobacco smoke. Morphometric and functional analysis |
| title_sort | emphysema model in rats exposed to tobacco smoke morphometric and functional analysis |
| topic | RC Medicina Interna, Psiquiatría, Neurología |
| url | http://eprints.uanl.mx/11730/1/S1665579616300606_S300_en.pdf |
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