Ebola virus disease 2014

Ebola virus disease was irst described in 1976 originating from the Ebola River in the Democratic Republic of Congo. Since then, Ebola virus has become an important public health threat in Africa, and now it is of great concern worldwide due to the recent outbreaks (9216 cases with 4555 deaths up t...

Descripción completa

Detalles Bibliográficos
Autores principales: Galán Huerta, Kame Alberto, Arellanos Soto, Daniel, Rivas Estilla, Ana María, Bravo de la Cruz, Verónica, Ramos Jiménez, Javier
Formato: Artículo
Lenguaje:inglés
Publicado: UANL. Facultad de Medicina 2014
Materias:
Acceso en línea:http://eprints.uanl.mx/11484/1/X1665579614676072_S300_en.pdf
_version_ 1824413364337508352
author Galán Huerta, Kame Alberto
Arellanos Soto, Daniel
Rivas Estilla, Ana María
Bravo de la Cruz, Verónica
Ramos Jiménez, Javier
author_facet Galán Huerta, Kame Alberto
Arellanos Soto, Daniel
Rivas Estilla, Ana María
Bravo de la Cruz, Verónica
Ramos Jiménez, Javier
author_sort Galán Huerta, Kame Alberto
collection Repositorio Institucional
description Ebola virus disease was irst described in 1976 originating from the Ebola River in the Democratic Republic of Congo. Since then, Ebola virus has become an important public health threat in Africa, and now it is of great concern worldwide due to the recent outbreaks (9216 cases with 4555 deaths up to October 20th, 2014), and it is so far the largest and deadliest recorded in history. Five Ebola virus species have been identiied (including Zaire, Sudan, Ivory Coast, Reston, and Bundibugyo Ebola virus), and four of them have proved to be highly pathogenic for both human and non-human primates, causing viral hemorrhagic fever with case fatality rates of up to 90%, for which no approved therapeutics or vaccines are currently available. Ebola virus infections are characterized by immune suppression and a systemic inlammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock. The major affected countries, Sierra Leone, Guinea, Liberia, and Nigeria, have been struggling to contain and to mitigate the outbreak. Gene sequencing of the 2014 virus (2014WA) outbreak has demonstrated 98% homology with the Zaire Ebola virus, with a 49% case fatality ratio across the affected countries. In this review the characteristics of the viruses, pathogenesis, diagnosis, treatment, and the cases reported in health care workers (HCW) are described, as well as a summary of outbreaks of the virus since its discovery, including these last two outbreaks in Africa.
format Article
id eprints-11484
institution UANL
language English
publishDate 2014
publisher UANL. Facultad de Medicina
record_format eprints
spelling eprints-114842016-10-28T20:51:35Z http://eprints.uanl.mx/11484/ Ebola virus disease 2014 Galán Huerta, Kame Alberto Arellanos Soto, Daniel Rivas Estilla, Ana María Bravo de la Cruz, Verónica Ramos Jiménez, Javier RC Medicina Interna, Psiquiatría, Neurología Ebola virus disease was irst described in 1976 originating from the Ebola River in the Democratic Republic of Congo. Since then, Ebola virus has become an important public health threat in Africa, and now it is of great concern worldwide due to the recent outbreaks (9216 cases with 4555 deaths up to October 20th, 2014), and it is so far the largest and deadliest recorded in history. Five Ebola virus species have been identiied (including Zaire, Sudan, Ivory Coast, Reston, and Bundibugyo Ebola virus), and four of them have proved to be highly pathogenic for both human and non-human primates, causing viral hemorrhagic fever with case fatality rates of up to 90%, for which no approved therapeutics or vaccines are currently available. Ebola virus infections are characterized by immune suppression and a systemic inlammatory response that causes impairment of the vascular, coagulation, and immune systems, leading to multiorgan failure and shock, and thus, in some ways, resembling septic shock. The major affected countries, Sierra Leone, Guinea, Liberia, and Nigeria, have been struggling to contain and to mitigate the outbreak. Gene sequencing of the 2014 virus (2014WA) outbreak has demonstrated 98% homology with the Zaire Ebola virus, with a 49% case fatality ratio across the affected countries. In this review the characteristics of the viruses, pathogenesis, diagnosis, treatment, and the cases reported in health care workers (HCW) are described, as well as a summary of outbreaks of the virus since its discovery, including these last two outbreaks in Africa. UANL. Facultad de Medicina 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/11484/1/X1665579614676072_S300_en.pdf http://eprints.uanl.mx/11484/1.haspreviewThumbnailVersion/X1665579614676072_S300_en.pdf Galán Huerta, Kame Alberto y Arellanos Soto, Daniel y Rivas Estilla, Ana María y Bravo de la Cruz, Verónica y Ramos Jiménez, Javier (2014) Ebola virus disease 2014. Medicina universitaria, 16 (65). pp. 207-215. ISSN 1665-5796
spellingShingle RC Medicina Interna, Psiquiatría, Neurología
Galán Huerta, Kame Alberto
Arellanos Soto, Daniel
Rivas Estilla, Ana María
Bravo de la Cruz, Verónica
Ramos Jiménez, Javier
Ebola virus disease 2014
thumbnail https://rediab.uanl.mx/themes/sandal5/images/online.png
title Ebola virus disease 2014
title_full Ebola virus disease 2014
title_fullStr Ebola virus disease 2014
title_full_unstemmed Ebola virus disease 2014
title_short Ebola virus disease 2014
title_sort ebola virus disease 2014
topic RC Medicina Interna, Psiquiatría, Neurología
url http://eprints.uanl.mx/11484/1/X1665579614676072_S300_en.pdf
work_keys_str_mv AT galanhuertakamealberto ebolavirusdisease2014
AT arellanossotodaniel ebolavirusdisease2014
AT rivasestillaanamaria ebolavirusdisease2014
AT bravodelacruzveronica ebolavirusdisease2014
AT ramosjimenezjavier ebolavirusdisease2014