Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus
Objective: To compare the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the “Dr. José Eleuterio González” University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospectiv...
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| Format: | Article |
| Language: | English |
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UANL. Facultad de Medicina
2014
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| Online Access: | http://eprints.uanl.mx/11456/1/X1665579614675853_S300_en.pdf |
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| author | Cruz Ferretti, Ulises Llanes Garza, Hilda Alicia López Cabrera, Norma Guadalupe Espinosa Galindo, Ana María Palacios Ríos, Dionicio Cano García, Martha Araceli Estrada Solís, Yesenia Nohemí |
| author_facet | Cruz Ferretti, Ulises Llanes Garza, Hilda Alicia López Cabrera, Norma Guadalupe Espinosa Galindo, Ana María Palacios Ríos, Dionicio Cano García, Martha Araceli Estrada Solís, Yesenia Nohemí |
| author_sort | Cruz Ferretti, Ulises |
| collection | Repositorio Institucional |
| description | Objective: To compare the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the “Dr. José Eleuterio González” University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospective, randomized study of 28 patients (14 per group) receiving neuraxial morphine analgesia was conducted, which was registered and approved by the ethics Committee of the Institution and patients agreed to participate in the study under informed consent. The results were segmented and contrasted (according to drug) by hypothesis testing; the association was determined by X2 with a 95% conidence interval (CI). Results: Pruritus was effectively resolved in both groups and no signiicant difference was found in the rest of the variables. An increase in the visual analogue scale (eVA) was observed at 6 and 12 hours for the ondansetron group, which was statistically signiicant (p≤0.05), however both groups had an eVA of less than 3. Conclusions: When comparing the eficacy and safety of ondansetron 4 mg vs. nalbuphine 4 mg for the treatment of neuraxial morphine induced pruritus, the only signiicant difference found was the mean eVA at 6 and 12 hours, favoring the ondansetron group. However, both groups scored less than 3 on the eVA. Therefore, we consider that both treatments are effective and safe in the treatment of pruritus caused by neuraxial morphine. |
| format | Article |
| id | eprints-11456 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| publisher | UANL. Facultad de Medicina |
| record_format | eprints |
| spelling | eprints-114562021-05-18T17:43:58Z http://eprints.uanl.mx/11456/ Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus Cruz Ferretti, Ulises Llanes Garza, Hilda Alicia López Cabrera, Norma Guadalupe Espinosa Galindo, Ana María Palacios Ríos, Dionicio Cano García, Martha Araceli Estrada Solís, Yesenia Nohemí R Medicina en General Objective: To compare the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphine-induced pruritus, in patients at the “Dr. José Eleuterio González” University Hospital from September 2012 to August 2013. Material and methods: A controlled, prospective, randomized study of 28 patients (14 per group) receiving neuraxial morphine analgesia was conducted, which was registered and approved by the ethics Committee of the Institution and patients agreed to participate in the study under informed consent. The results were segmented and contrasted (according to drug) by hypothesis testing; the association was determined by X2 with a 95% conidence interval (CI). Results: Pruritus was effectively resolved in both groups and no signiicant difference was found in the rest of the variables. An increase in the visual analogue scale (eVA) was observed at 6 and 12 hours for the ondansetron group, which was statistically signiicant (p≤0.05), however both groups had an eVA of less than 3. Conclusions: When comparing the eficacy and safety of ondansetron 4 mg vs. nalbuphine 4 mg for the treatment of neuraxial morphine induced pruritus, the only signiicant difference found was the mean eVA at 6 and 12 hours, favoring the ondansetron group. However, both groups scored less than 3 on the eVA. Therefore, we consider that both treatments are effective and safe in the treatment of pruritus caused by neuraxial morphine. UANL. Facultad de Medicina 2014 Article PeerReviewed text en cc_by_nc_nd http://eprints.uanl.mx/11456/1/X1665579614675853_S300_en.pdf http://eprints.uanl.mx/11456/1.haspreviewThumbnailVersion/X1665579614675853_S300_en.pdf Cruz Ferretti, Ulises y Llanes Garza, Hilda Alicia y López Cabrera, Norma Guadalupe y Espinosa Galindo, Ana María y Palacios Ríos, Dionicio y Cano García, Martha Araceli y Estrada Solís, Yesenia Nohemí (2014) Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus. Medicina universitaria, 16 (64). pp. 107-111. ISSN 1665-5796 |
| spellingShingle | R Medicina en General Cruz Ferretti, Ulises Llanes Garza, Hilda Alicia López Cabrera, Norma Guadalupe Espinosa Galindo, Ana María Palacios Ríos, Dionicio Cano García, Martha Araceli Estrada Solís, Yesenia Nohemí Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| title_full | Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| title_fullStr | Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| title_full_unstemmed | Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| title_short | Comparison of the eficacy and safety of 4 mg of ondansetron vs. 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| title_sort | comparison of the eficacy and safety of 4 mg of ondansetron vs 4 mg of nalbuphine for the treatment of neuraxial morphineinduced pruritus |
| topic | R Medicina en General |
| url | http://eprints.uanl.mx/11456/1/X1665579614675853_S300_en.pdf |
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