In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus
Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysa...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Springer
2014
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| Online Access: | http://eprints.uanl.mx/11163/1/Invitro.pdf |
| _version_ | 1824413296272343040 |
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| author | Trejo Ávila, Laura M. Morales Martinez, M. E. Ricque Marie, Denis Cruz Suárez, Lucía Elizabeth Zapata Benavides, Pablo Morán Santibáñez, Karla Selene Rodríguez Padilla, Cristina |
| author_facet | Trejo Ávila, Laura M. Morales Martinez, M. E. Ricque Marie, Denis Cruz Suárez, Lucía Elizabeth Zapata Benavides, Pablo Morán Santibáñez, Karla Selene Rodríguez Padilla, Cristina |
| author_sort | Trejo Ávila, Laura M. |
| collection | Repositorio Institucional |
| description | Canine distemper virus (CDV) is a morbillivirus
related to measles virus that infects dogs and other
carnivores. CDV has a significant global impact on animal
health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysaccharides exhibit antiviral properties both in vivo and in vitro, despite their low cytotoxicity to host cells. Fucoidan is a sulfated polysaccharide found in the cell wall matrix of brown algae. In this study, we evaluated in vitro anti-CDV activity of fucoidan, which was derived from Cladosiphon okamuranus. Fucoidan actively inhibited CDV replication in Vero cells at a 50% inhibitory concentration (IC50) of 0.1 lg/ml. The derived selectivity index (SI50) was[20,000. This polysaccharide
likely inhibits viral infection by interference in the early steps and by inhibiting CDV-mediated cell fusion. Fucoidan may be useful in development of pharmacological
strategies to treat and control CDV infection. |
| format | Article |
| id | eprints-11163 |
| institution | UANL |
| language | English |
| publishDate | 2014 |
| publisher | Springer |
| record_format | eprints |
| spelling | eprints-111632021-07-19T14:43:15Z http://eprints.uanl.mx/11163/ In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus Trejo Ávila, Laura M. Morales Martinez, M. E. Ricque Marie, Denis Cruz Suárez, Lucía Elizabeth Zapata Benavides, Pablo Morán Santibáñez, Karla Selene Rodríguez Padilla, Cristina SH Acuacultura / Pesca Canine distemper virus (CDV) is a morbillivirus related to measles virus that infects dogs and other carnivores. CDV has a significant global impact on animal health; however, there is no current antiviral treatment for CDV infection. In recent years, it has been demonstrated that sulfated polysaccharides exhibit antiviral properties both in vivo and in vitro, despite their low cytotoxicity to host cells. Fucoidan is a sulfated polysaccharide found in the cell wall matrix of brown algae. In this study, we evaluated in vitro anti-CDV activity of fucoidan, which was derived from Cladosiphon okamuranus. Fucoidan actively inhibited CDV replication in Vero cells at a 50% inhibitory concentration (IC50) of 0.1 lg/ml. The derived selectivity index (SI50) was[20,000. This polysaccharide likely inhibits viral infection by interference in the early steps and by inhibiting CDV-mediated cell fusion. Fucoidan may be useful in development of pharmacological strategies to treat and control CDV infection. Springer 2014 Article PeerReviewed text en http://eprints.uanl.mx/11163/1/Invitro.pdf http://eprints.uanl.mx/11163/1.haspreviewThumbnailVersion/Invitro.pdf Trejo Ávila, Laura M. y Morales Martinez, M. E. y Ricque Marie, Denis y Cruz Suárez, Lucía Elizabeth y Zapata Benavides, Pablo y Morán Santibáñez, Karla Selene y Rodríguez Padilla, Cristina (2014) In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus. Virus disease, 25. pp. 474-480. ISSN 1201-9712 http://link.springer.com/article/10.1007/s13337-014-0228-6 10.1007/s13337-014-0228-6 |
| spellingShingle | SH Acuacultura / Pesca Trejo Ávila, Laura M. Morales Martinez, M. E. Ricque Marie, Denis Cruz Suárez, Lucía Elizabeth Zapata Benavides, Pablo Morán Santibáñez, Karla Selene Rodríguez Padilla, Cristina In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| thumbnail | https://rediab.uanl.mx/themes/sandal5/images/online.png |
| title | In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| title_full | In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| title_fullStr | In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| title_full_unstemmed | In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| title_short | In vitro anti-canine distemper virus activity of fucoidan extracted from the brown alga Cladosiphon okamuranus |
| title_sort | in vitro anti canine distemper virus activity of fucoidan extracted from the brown alga cladosiphon okamuranus |
| topic | SH Acuacultura / Pesca |
| url | http://eprints.uanl.mx/11163/1/Invitro.pdf |
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